Diagnostic accuracy of serum alanine aminotransferase as biomarker for nonalcoholic fatty liver disease and insulin resistance in healthy subjects, using 3T MR spectroscopy

Recognition of the close relationship of nonalcoholic fatty liver disease (NAFLD) with diabetes mellitus 2, obesity, metabolic syndrome, and cardiovascular disease has stimulated growing interest in NAFLD as a public health problem. Serum alanine aminotransferase (ALT) has been proposed as a marker...

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Bibliographic Details
Published in:Medicine (Baltimore) 2017-04, Vol.96 (17), p.e6770-e6770
Main Authors: Martin-Rodriguez, Jose Luis, Gonzalez-Cantero, Jorge, Gonzalez-Cantero, Alvaro, Arrebola, Juan Pedro, Gonzalez-Calvin, Jorge Luis
Format: Article
Language:English
Subjects:
Adult
Aged
Alanine Transaminase - blood
Anthropometry
Area Under Curve
Biomarkers - blood
Diagnostic Accuracy Study
European Continental Ancestry Group
Female
Humans
Insulin Resistance - physiology
Liver - diagnostic imaging
Liver - metabolism
Male
Middle Aged
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - diagnostic imaging
Non-alcoholic Fatty Liver Disease - enzymology
Proton Magnetic Resonance Spectroscopy
Regression Analysis
ROC Curve
Triglycerides - metabolism
Young Adult
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Summary:Recognition of the close relationship of nonalcoholic fatty liver disease (NAFLD) with diabetes mellitus 2, obesity, metabolic syndrome, and cardiovascular disease has stimulated growing interest in NAFLD as a public health problem. Serum alanine aminotransferase (ALT) has been proposed as a marker of NAFLD, but levels are within the range currently considered "normal" in a large proportion of NAFLD subjects.The aim of the study was to determine the diagnostic accuracy of serum ALT for identifying individuals with NAFLD, using 3-Tesla (T) magnetic resonance spectroscopy (H-MRS).A cross-sectional study was conducted in 129 healthy subjects. Liver triglyceride content was quantified by H-MRS. NAFLD was defined as liver triglyceride content greater than 5.56%.Liver triglyceride content was >5.56% in 79 participants (NAFLD) and lower in the remaining 50 (normal). Serum ALT levels correlated positively with liver triglyceride content (r = 0.58, P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000006770