Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent

Search for medicinal plants to treat kidney disorders is an important topic on phytotherapeutical research. Plumbago zeylanica L. is an important medicinal plant with hepatoprotective, anti-inflammatory, anti-diabetic, anti-cancer and anti-hyperlipidemic activities. In the present study, the protect...

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Bibliographic Details
Published in:Saudi journal of biological sciences 2017-05, Vol.24 (4), p.760-766
Main Authors: Rajakrishnan, R., Lekshmi, R., Benil, P.B., Thomas, J., AlFarhan, A.H., Rakesh, V., Khalaf, S.
Format: Article
Language:English
Subjects:
Cisplatin
Histopathology
Lipid peroxidation
Nephrotoxicity
Original
Phytochemical screening
السمية الكلوية
الكيمياء التحليلية
النباتات
بيروكسيد الدهون
سيسبلاتين
علم الأمراض التشريحي
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Summary:Search for medicinal plants to treat kidney disorders is an important topic on phytotherapeutical research. Plumbago zeylanica L. is an important medicinal plant with hepatoprotective, anti-inflammatory, anti-diabetic, anti-cancer and anti-hyperlipidemic activities. In the present study, the protective effect of hydroalcoholic extract of P. zeylanica (HAPZ) in cisplatin induced nephrotoxicity was analyzed in Swiss albino mice. Treatment with higher dose (400mg/kg) of HAPZ significantly reversed the adverse effect of cisplatin on kidney weight, serum urea and creatinine, indicating their renoprotective effect. The antioxidant effect of the drug is evident from its significant effect on Catalase, Glutathione peroxidase and lipid peroxidation activities.
ISSN:1319-562X
2213-7106
DOI:10.1016/j.sjbs.2017.01.001