Evaluation of Herb-Drug Interactions of Hovenia dulcis Fruit Extracts

(Rhamnaceae) fruits are popularly used as herbal medicines or dietary supplements in Asian countries due to functions such as liver protection and detoxification from alcohol poisoning. Accordingly, it is very likely for dietary supplemental products, including fruit extracts, to be taken with presc...

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Bibliographic Details
Published in:Pharmacognosy Magazine 2017-04, Vol.13 (50), p.236-239
Main Authors: Park, Jong Suk, Rehman, Shaheed Ur, Kim, In Sook, Choi, Min Sun, Na, Chun-Soo, Yoo, Hye Hyun
Format: Article
Language:English
Subjects:
Alcohol
Antioxidants
Chromatography
Cytochrome
Dehydrogenases
Diabetes
Drugs
Enzymes
Food
Fruits
Herbal medicine
Metabolism
Metabolites
Original
Pharmaceutical sciences
Pharmacy
Rodents
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Summary:(Rhamnaceae) fruits are popularly used as herbal medicines or dietary supplements in Asian countries due to functions such as liver protection and detoxification from alcohol poisoning. Accordingly, it is very likely for dietary supplemental products, including fruit extracts, to be taken with prescription drugs. In this study, possible food-drug interactions involving fruit extracts were evaluated based on the inhibition of cytochrome P450 (CYP) enzyme activity. The water extract of fruit extracts was incubated in human liver microsomes with CYP-specific substrates. The formation of the CYP-specific metabolites was measured using liquid chromatography-tandem mass spectrometry. fruit extracts showed negligible effects on seven CYP isozyme activities at all concentrations tested. This result suggests that fruit extracts may have minimal pharmacokinetic interactions with coadministered drugs through the modulation of CYP enzymes. Food-drug interactions involving fruit extracts were evaluated.The inhibition of CYPs by extracts was tested. extracts showed negligible effects on CYP activities. extracts may have minimal pharmacokinetic interactions with co-administered drugs. CYP: cytochrome P450 enzymes, HPLC: High performance liquid chromatography, LC-MS/MS : liquid chromatography-tandem mass spectrometry, MRM: multiple-reaction monitoring.
ISSN:0973-1296
0976-4062
DOI:10.4103/0973-1296.204552