Transition to resistance: An unexpected role of the EMT in cancer chemoresistance

Two recent studies provide intriguing evidence that challenges the role of the epithelial–mesenchymal transition (EMT) as a critical mediator of cancer metastasis, while revealing an unexpected role in cancer drug resistance.1,2 While these findings may not settle the EMT's role in metastasis,...

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Bibliographic Details
Published in:Genes & diseases 2016-03, Vol.3 (1), p.3-6
Main Authors: Wang, Jing, Wei, Qiang, Wang, Xin, Tang, Shengli, Liu, Hao, Zhang, Fugui, Mohammed, Maryam K., Huang, Jiayi, Guo, Dan, Lu, Minpeng, Liu, Feng, Liu, Jianxiang, Ma, Chao, Hu, Xue, Haydon, Rex C., He, Tong-Chuan, Luu, Hue H.
Format: Article
Language:English
Subjects:
Breast cancer
Cancer metastasis
Chemoresistance
Drug resistance
EMT
Pancreatic cancer
Targeted therapies
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Summary:Two recent studies provide intriguing evidence that challenges the role of the epithelial–mesenchymal transition (EMT) as a critical mediator of cancer metastasis, while revealing an unexpected role in cancer drug resistance.1,2 While these findings may not settle the EMT's role in metastasis, these studies suggest that targeting the EMT may inhibit both cancer metastasis and chemoresistance.
ISSN:2352-3042
2352-4820
2352-3042
DOI:10.1016/j.gendis.2016.01.002