Wnt Signaling in Normal and Malignant Stem Cells

Wnt signaling plays important roles in stem cell self-renewal and differentiation in adults as well as in embryonic development. Mutations that activate canonical Wnt/β-catenin signaling also initiate and maintain several cancer states, including colorectal cancer and leukemia, and hence Wnt inhibit...

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Bibliographic Details
Published in:Current stem cell reports 2016-12, Vol.2 (4), p.379-387
Main Authors: Bhavanasi, Dheeraj, Klein, Peter S.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Cancer
Cell Biology
Cell differentiation
Cell self-renewal
Colorectal carcinoma
Embryogenesis
Gene Therapy
Homeostasis
Immunology
Life Sciences
Role of Classical Signaling Pathways in Stem Cell Maintenance (A Cardoso and N Carlesso
Section Editors
Stem Cells
Topical Collection on Role of Classical Signaling Pathways in Stem Cell Maintenance
Wnt protein
β-Catenin
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Summary:Wnt signaling plays important roles in stem cell self-renewal and differentiation in adults as well as in embryonic development. Mutations that activate canonical Wnt/β-catenin signaling also initiate and maintain several cancer states, including colorectal cancer and leukemia, and hence Wnt inhibitors are currently being explored as therapeutic options. In this review, we summarize previous studies and update recent findings on canonical Wnt signaling and its components, as well as their roles in somatic stem cell homeostasis and maintenance of cancer-initiating cells.
ISSN:2198-7866
2198-7866
DOI:10.1007/s40778-016-0068-y