Effect of Tamarindus indica L. and Manihot esculenta Extracts on Antibiotic-resistant Bacteria

• Published in: Pharmacognosy research 2017-04, Vol.9 (2), p.195-199
• Main Authors: Lima, Zenon Machado, da Trindade, Lenilson Santos, Santana, Genelane Cruz, Padilha, Francine Ferreira, da Costa Mendonça, Marcelo, da Costa, Luiz Pereira, López, Jorge A, Macedo, Maria Lucila Hernández
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 0976-4836; 0974-8490
• DOI: 10.4103/0974-8490.204648

The chemical composition of plants used in traditional medicine exhibits biologically active compounds, such as tannins, flavonoids, and alkaloids and becomes a promising approach to treat microbial infections, mainly with drug-resistant bacteria. The aim of the present study was to evaluate the hydroethanolic leaf extracts of ( ) and ( ) as antimicrobial potential against clinical isolated and Methicillin-resistant . Hydroethanolic leaf extracts were prepared and characterized by high-performance liquid chromatography/diode array detection, Fourier transform infrared, 1,1-diphenyl-2-picrylhydrazyl, and ultraviolet-visible methods. The antimicrobial activity against four strains of clinical relevance was evaluated by the microdilution method at minimum inhibitory concentrations. Phenolic compounds such as flavonoids were detected in the plant extracts. extract at 500 μg/mL showed antimicrobial activity against and ; however, showed only activity against in this concentration. Our results suggested that polyphenols and flavonoids present in leaf extracts are a potential source of antimicrobial compound. The extract showed antibacterial activity against and while had effect only on meropenem resistant. Antibacterial effect of and leaf extract was evaluated. extract displayed activity against and strains. showed effect on meropenem resistant. BHI: Agar brain heart infusion, CAPES: Coordination for the improvement of higher education personnel, DPPH: 1,1-diphenyl-2-picrylhydrazyl, FAPITEC/SE: Foundation for support to research and technological innovation of the state of sergipe, FTIR: Fourier transform infrared spectroscopy, HPLC: High-performance liquid chromatography, KBr: Potassium bromide, MIC: Minimum inhibitory concentration, MRSA: Methicillin-resistant , RSC: Radical scavenging capacity, UV-vis: Ultraviolet-visible.