Picoliter‐volume inkjet printing into planar microdevice reservoirs for low‐waste, high‐capacity drug loading

Oral delivery of therapeutics is the preferred route for systemic drug administration due to ease of access and improved patient compliance. However, many therapeutics suffer from low oral bioavailability due to low pH and enzymatic conditions, poor cellular permeability, and low residence time. Mic...

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Bibliographic Details
Published in:Bioengineering & translational medicine 2017-03, Vol.2 (1), p.9-16
Main Authors: Fox, Cade B., Nemeth, Cameron L., Chevalier, Rachel W., Cantlon, Joshua, Bogdanoff, Derek B., Hsiao, Jeff C., Desai, Tejal A.
Format: Article
Language:English
Subjects:
Advantages
Bioavailability
Biological products
drug delivery
Drug delivery systems
Drug dosages
Epithelium
Hydrogels
Inkjet printing
Insulin
Medical wastes
Methods
microdevices
nanobiotechnology
Nanotechnology
Permeability
Rapid Communication
Reservoirs
Silicon wafers
topotecan
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Summary:Oral delivery of therapeutics is the preferred route for systemic drug administration due to ease of access and improved patient compliance. However, many therapeutics suffer from low oral bioavailability due to low pH and enzymatic conditions, poor cellular permeability, and low residence time. Microfabrication techniques have been used to create planar, asymmetric microdevices for oral drug delivery to address these limitations. The geometry of these microdevices facilitates prolonged drug exposure with unidirectional release of drug toward gastrointestinal epithelium. While these devices have significantly enhanced drug permeability in vitro and in vivo, loading drug into the micron‐scale reservoirs of the devices in a low‐waste, high‐capacity manner remains challenging. Here, we use picoliter‐volume inkjet printing to load topotecan and insulin into planar microdevices efficiently. Following a simple surface functionalization step, drug solution can be spotted into the microdevice reservoir. We show that relatively high capacities of both topotecan and insulin can be loaded into microdevices in a rapid, automated process with little to no drug waste.
ISSN:2380-6761
2380-6761
DOI:10.1002/btm2.10053