Primary diffuse large B cell lymphoma of the uterine cervix successfully treated by combined chemotherapy alone: A case report

• Published in: Medicine (Baltimore) 2017-05, Vol.96 (19), p.e6846-e6846
• Main Authors: Cubo, Ana María, Soto, Zandra Mileny, Cruz, Miguel Ángel, Doyague, María José, Sancho, Verónica, Fraino, Aurymar, Blanco, Óscar, Puig, Noemi, Alcoceba, Miguel, González, Marcos, Sayagués, José María
• Format: Article
• Language: English
• Subjects: Antineoplastic Agents - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cervix Uteri - diagnostic imaging; Cervix Uteri - drug effects; Cervix Uteri - pathology; Clinical Case Report; Cyclophosphamide - therapeutic use; Diagnosis, Differential; Doxorubicin - therapeutic use; Female; Humans; Lymphoma, Large B-Cell, Diffuse - diagnosis; Lymphoma, Large B-Cell, Diffuse - drug therapy; Lymphoma, Large B-Cell, Diffuse - pathology; Middle Aged; Prednisone - therapeutic use; Rituximab - therapeutic use; Uterine Cervical Neoplasms - diagnosis; Uterine Cervical Neoplasms - drug therapy; Uterine Cervical Neoplasms - pathology; Vincristine - therapeutic use
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000006846

Primary lymphomas of the uterine cervix are a rare disease. They are often misdiagnosed because of their rarity and because they can be easily confused with a squamous cell carcinoma of the cervix, as they are usually presented as exophytic mass with vaginal bleeding as their most common symptoms. Nevertheless, considering that both the prognosis and the treatment are completely different between them, differential diagnosis should be taken into account. A case of a 51-year-old woman with a primary diffuse large B-cell lymphoma of the cervix is presented. Diagnosis of this tumor was a challenge for pathologists and clinicians, as four biopsies were needed to achieve a final diagnosis. Patient was successfully treated with combined Rituximab and chemotherapy (R-CHOP) alone. Complete remission, confirmed through biopsy, was reached after six courses of chemotherapy. At 2-years follow up, patient is alive and free of disease. Considering that the prognosis and treatment of primary malignant lymphoma of the cervix are completely different than that of the squamous cell carcinoma, awareness of this disease should be considered in the differential diagnosis.