Mechanics of epithelial tissues during gap closure

The closure of gaps is crucial to maintaining epithelium integrity during developmental and repair processes such as dorsal closure and wound healing. Depending on biochemical as well as physical properties of the microenvironment, gap closure occurs through assembly of multicellular actin-based con...

Full description

Saved in:
Bibliographic Details
Published in:Current opinion in cell biology 2016-10, Vol.42, p.52-62
Main Authors: Begnaud, Simon, Chen, Tianchi, Delacour, Delphine, Mège, René-Marc, Ladoux, Benoît
Format: Article
Language:English
Subjects:
Actins
Actomyosin - metabolism
Animals
Biomechanical Phenomena
Body Patterning
Cellular Biology
Epithelial Cells - cytology
Epithelial Cells - metabolism
Epithelium - physiology
Humans
Internal Medicine
Life Sciences
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The closure of gaps is crucial to maintaining epithelium integrity during developmental and repair processes such as dorsal closure and wound healing. Depending on biochemical as well as physical properties of the microenvironment, gap closure occurs through assembly of multicellular actin-based contractile cables and/or protrusive activity of cells lining the gap. This review discusses the relative contributions of ‘purse-string’ and cell crawling mechanisms regulated by cell–substrate and cell–cell interactions, cellular mechanics and physical constraints from the environment.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2016.04.006