Primordial odontogenic tumor: An immunohistochemical profile

Primordial Odontogenic Tumor (POT) is a recently described odontogenic tumor characterized by a variably cellular loose fibrous tissue with areas similar to the dental papilla, covered by cuboidal to columnar epithelium that resembles the internal epithelium of the enamel organ, surrounded at least...

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Published in:Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2017-05, Vol.22 (3), p.e314-e323
Main Authors: Bologna-Molina, R, Mikami, T, Pereira-Prado, V, Pires, F-R, Carlos-Bregni, R, Mosqueda-Taylor, A
Format: Article
Language:English
Subjects:
Adolescent
Antibodies, Neoplasm - analysis
Child, Preschool
Dentistry
Female
Humans
Immunohistochemistry
Jaw Neoplasms - chemistry
Jaw Neoplasms - immunology
Jaw Neoplasms - pathology
Male
Odontogenic Tumors - chemistry
Odontogenic Tumors - immunology
Odontogenic Tumors - pathology
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Summary:Primordial Odontogenic Tumor (POT) is a recently described odontogenic tumor characterized by a variably cellular loose fibrous tissue with areas similar to the dental papilla, covered by cuboidal to columnar epithelium that resembles the internal epithelium of the enamel organ, surrounded at least partly by a delicate fibrous capsule. The purpose of this study was to investigate the possible histogenesis and biological behavior of this rare tumor by means of a wide immunohistochemical analysis of its epithelial and mesenchymal components. The immunoexpression of twenty-three different antibodies were evaluated in four cases of POT. The epithelial cells that cover the periphery of the tumor showed immunopositivity for Cytokeratins 14 and 19, while Amelogenin, Glut-1, MOC-31, Caveolin-1. Galectin-3, PITX2, p53, Bax, Bcl-2, Survivin and PTEN were variably expressed in focal areas. The mesenchymal component of the tumor was positive for Vimentin, Syndecan-1, PITX2, Endoglin (CD105), CD 34, Cyclin D1, Bax, Bcl-2, Survivin and p53. PTEN and CD 90 showed a moderate positivity. BRAF V600E and Calretinin were negative in all samples. Cell proliferation markers (Ki-67, MCM-7) were expressed in
ISSN:1698-6946
1698-4447
1698-6946
DOI:10.4317/medoral.21859