The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study

• Published in: International Brazilian Journal of Urology 2017-04, Vol.43 (2), p.345-355
• Main Authors: Benli, Erdal, Ayyildiz, Sema Nur, Cirrik, Selma, Koktürk, Sibel, Cirakoglu, Abdullah, Noyan, Tevfik, Ayyildiz, Ali, Germiyanoglu, Cankon
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury; Kidney Failure, Chronic; Original; Renal Insufficiency; Tadalafil
• ISSN: 1677-5538; 1677-6119; 1677-5538; 1677-6119
• DOI: 10.1590/s1677-5538.ibju.2016.0075

ABSTRACT Introduction Sepsis is an inflammatory reaction to bacteria involving the whole body and is a significant cause of mortality and economic costs. The purpose of this research was to determine whether tadalafil exhibits a preventive effect on sepsis in a septic model induced in rats with cecal ligation and puncture (CLP). Materials and Methods Rats were randomly separated into groups, 10 rats in each: (i) a sham (control) group, (ii) an untreated sepsis group, (iii) a sepsis group treated with 5mg/kg tadalafil and (iv) a sepsis group treated with 10mg/kg tadalafil. A polymicrobial sepsis model was induced in rats using CLP. Rats were sacrificed after 16h, and blood and kidney tissues were collected for biochemical and histopathological study. Results Levels of the inflammatory parameter IL-6 decreased significantly in the sepsis groups receiving tadalafil in comparison with the untreated sepsis group (p