Long-Term Sensitization Training in "Aplysia" Decreases the Excitability of a Decision-Making Neuron through a Sodium-Dependent Mechanism

In "Aplysia," long-term sensitization (LTS) occurs concurrently with a suppression of feeding. At the cellular level, the suppression of feeding is accompanied by decreased excitability of decision-making neuron B51. We examined the contribution of voltage-gated Na[superscript +] and K[sup...

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Bibliographic Details
Published in:Learning & memory (Cold Spring Harbor, N.Y.) N.Y.), 2017-06, Vol.24 (6), p.257-261
Main Authors: Hernandez, John S, Wainwright, Marcy L, Mozzachiodi, Riccardo
Format: Article
Language:English
Subjects:
4-Aminopyridine - pharmacology
Action Potentials - drug effects
Action Potentials - physiology
Animals
Aplysia - physiology
Brain Hemisphere Functions
Brief Communication
Cognitive Processes
Comparative Analysis
Cytology
Decision Making
Decision Making - physiology
Diagnostic Tests
Drug Use
Electric Stimulation
Food
Long-Term Potentiation - drug effects
Long-Term Potentiation - physiology
Neurons, Afferent - drug effects
Neurons, Afferent - physiology
Potassium Channel Blockers - pharmacology
Sodium - metabolism
Tetraethylammonium - pharmacology
Training
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Summary:In "Aplysia," long-term sensitization (LTS) occurs concurrently with a suppression of feeding. At the cellular level, the suppression of feeding is accompanied by decreased excitability of decision-making neuron B51. We examined the contribution of voltage-gated Na[superscript +] and K[superscript +] channels to B51 decreased excitability. In a pharmacologically isolated Na[superscript +] channels environment, LTS training significantly increased B51 firing threshold, compared with untrained controls. Conversely, in a pharmacologically isolated K[superscript +] channels environment, no differences were observed between trained and untrained animals in either amplitude or area of B51 K[superscript +]-dependent depolarizations. These findings suggest that Na[superscript +] channels contribute to the decrease in B51 excitability induced by LTS training.
ISSN:1072-0502
1549-5485
1549-5485
DOI:10.1101/lm.044883.116