Overexpression of Matrix Metalloproteinase 9 in Tumor Epithelial Cells Correlates with Colorectal Cancer Metastasis

Colorectal cancer mortality largely reflects metastasis, the spread of the disease to distant organs. Matrix metalloproteinase 9 (MMP‐9) is a key regulator of metastasis and a target for anticancer strategies in colon cancer. Here, the overexpression of MMP‐9 in pure tumor epithelial, but nor stroma...

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Bibliographic Details
Published in:Clinical and translational science 2008-09, Vol.1 (2), p.136-141
Main Authors: Zuzga, David S., Gibbons, Ahmara Vivian, Li, Peng, Lubbe, Wilhelm Johannes, Chervoneva, Inna, Pitari, Giovanni Mario
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers, Tumor - metabolism
Cell Compartmentation
Cell Separation
colorectal cancer
Colorectal Neoplasms - enzymology
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
disease stage
Epithelial Cells - enzymology
Epithelial Cells - pathology
Female
Gene Expression Regulation, Neoplastic
Humans
Intestinal Mucosa - pathology
Male
Matrix Metalloproteinase 9 - genetics
Matrix Metalloproteinase 9 - metabolism
metastasis
Middle Aged
MMP-9
Neoplasm Metastasis
Neoplasm Staging
Prognosis
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Summary:Colorectal cancer mortality largely reflects metastasis, the spread of the disease to distant organs. Matrix metalloproteinase 9 (MMP‐9) is a key regulator of metastasis and a target for anticancer strategies in colon cancer. Here, the overexpression of MMP‐9 in pure tumor epithelial, but nor stromal, cell populations was associated with metastatic progression of colorectal cancer, as defined by reverse transcriptase‐polymerase chain reaction (qRT‐PCR) and confirmed by immunostaining. Thus, cancer cell MMP‐9 represents a novel, selective prognostic and predictive factor that may be exploited for more effective disease stage stratification and therapeutic regimen selection in patients with colorectal cancer.
ISSN:1752-8054
1752-8062
DOI:10.1111/j.1752-8062.2008.00037.x