The role of circulating miR-146a in patients with rheumatoid arthritis treated by Tripterygium wilfordii Hook F

Rheumatoid arthritis (RA) is polygenic autoimmune disease with unclear etiology. MicroRNAs (miRNAs) play a critical role in the pathogenesis of RA. The objective of this study was to evaluate the role of miR-146a in patients with RA receiving Tripterygium wilfordii Hook F (TwHF) treatment.In total,...

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Bibliographic Details
Published in:Medicine (Baltimore) 2017-05, Vol.96 (20), p.e6775-e6775
Main Authors: Chen, Zhen-Zhou, Zhang, Xue-Dan, Chen, Ying, Wu, Ya-Bing
Format: Article
Language:English
Subjects:
Antirheumatic Agents - therapeutic use
Area Under Curve
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - drug therapy
Biomarkers - blood
Drugs, Chinese Herbal - therapeutic use
Female
Humans
Leukocytes, Mononuclear - metabolism
Male
MicroRNAs - blood
Middle Aged
Observational Study
Phytotherapy
Prognosis
Risk
ROC Curve
Severity of Illness Index
Treatment Outcome
Tripterygium
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Summary:Rheumatoid arthritis (RA) is polygenic autoimmune disease with unclear etiology. MicroRNAs (miRNAs) play a critical role in the pathogenesis of RA. The objective of this study was to evaluate the role of miR-146a in patients with RA receiving Tripterygium wilfordii Hook F (TwHF) treatment.In total, 69 patients with RA and 69 healthy controls (HC) were included in the study, and patients with RA received TwHF treatment for 24 weeks. Blood samples were collected from RA patients and HC, and peripheral blood mononuclear cells (PBMCs) were isolated. Expression of miR-146a was analyzed in RA patients (baseline, 12 weeks and 24 weeks) and HC.Circulating miR-146a expression was markedly increased in patients with RA compared with healthy controls (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000006775