Recent advances in the management of pruritus in chronic liver diseases

Pruritus is a symptom found in patients with chronic liver diseases,especially cholestatic liver diseases such as primary biliary cholangitis.This symptom impairs patient quality of life by disturbing sleep and may lead to consideration of liver transplantation.Mechanisms implicated in pruritus have...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2017-05, Vol.23 (19), p.3418-3426
Main Authors: Tajiri, Kazuto, Shimizu, Yukihiro
Format: Article
Language:English
Subjects:
Animals
Central Nervous System - metabolism
Cholestasis - complications
Chronic Disease
Fibrosis - complications
Gastroenterology - methods
Hepatitis B, Chronic - complications
Hepatitis C, Chronic - complications
Humans
Liver Diseases - complications
Liver Diseases - therapy
Liver Transplantation
Mice
Narcotic Antagonists - pharmacology
Peripheral Nervous System - metabolism
Phosphoric Diester Hydrolases - metabolism
Pruritus - complications
Pruritus - therapy
Quality of Life
Receptors, Opioid - chemistry
Review
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Summary:Pruritus is a symptom found in patients with chronic liver diseases,especially cholestatic liver diseases such as primary biliary cholangitis.This symptom impairs patient quality of life by disturbing sleep and may lead to consideration of liver transplantation.Mechanisms implicated in pruritus have been associated with the peripheral and central nervous systems,leading to the development of various therapeutic options.Little evidence for the efficacy of most of these treatments is currently available,indicating a need for further investigations.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v23.i19.3418