Combined assessment of myocardial damage and electrical disturbance in chronic heart failure

• Published in: World journal of cardiology 2017-05, Vol.9 (5), p.457-465
• Main Authors: Kadowaki, Shinpei, Watanabe, Tetsu, Otaki, Yoichiro, Narumi, Taro, Honda, Yuki, Takahashi, Hiroki, Arimoto, Takanori, Shishido, Tetsuro, Miyamoto, Takuya, Kubota, Isao
• Format: Article
• Language: English
• Subjects: Prospective Study
• ISSN: 1949-8462; 1949-8462
• DOI: 10.4330/wjc.v9.i5.457

AIM To investigate feasibility of combined assessment of biochemical and electrophysiological myocardial impairment markers risk-stratifying patients with chronic heart failure(CHF). METHODS Serum levels of heart-type fatty acid binding protein(H-FABP) as a marker of ongoing myocardial damage and QRS duration on electrocardiogram were measured at admission in 322 consecutive patients with CHF. A prolonged QRS duration was defined as 120 ms or longer. The cut-off value for H-FABP level(4.5 ng/mL) was determined from a previous study. Patients were prospectively followed during a median follow up period of 534 d. The primary endpoint was cardiac deaths and rehospitalization for worsening CHF.RESULTS There were 117 primary events, including 27 cardiac deaths and 90 rehospitalizations. Patients were stratified into four groups according to H-FABP level and QRS duration(≥ 120 ms). Multivariate analysis demonstrated that high H-FABP levels [hazard ratio(HR) = 1.745, P = 0.021] and QRS prolongation(HR1.612, P = 0.0258) were independent predictors of cardiac events. Kaplan-Meier analysis demonstrated that the combination of high H-FABP levels and QRS prolongation could be used to reliably stratify patients at high risk for cardiac events(log rank test P < 0.0001).CONCLUSION Combined assessment of myocardial damage and electrical disturbance can be used to risk-stratify patients with CHF.