Direct Regioselective Synthesis of Tetrazolium Salts by Activation of Secondary Amides under Mild Conditions

Tetrazolium salts are biologically active molecules that have found broad applications in biochemical assays. A regioselective synthesis of tetrazolium salts is described through a formal (3 + 2) cycloaddition. The possibility of employing simple amides and azides as starting material and the mild c...

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Bibliographic Details
Published in:Organic letters 2017-05, Vol.19 (10), p.2662-2665
Main Authors: Tona, Veronica, Maryasin, Boris, de la Torre, Aurélien, Sprachmann, Josefine, González, Leticia, Maulide, Nuno
Format: Article
Language:English
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Letter
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Summary:Tetrazolium salts are biologically active molecules that have found broad applications in biochemical assays. A regioselective synthesis of tetrazolium salts is described through a formal (3 + 2) cycloaddition. The possibility of employing simple amides and azides as starting material and the mild conditions allow a broad functional group tolerance.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b01004