Nuclear roles for cilia-associated proteins

Cilia appear to be derived, evolutionarily, from structures present in the ancestral (pre-ciliary) eukaryote, such as microtubule-based vesicle trafficking and chromosome segregation systems. Experimental observations suggest that the ciliary gate, the molecular complex that mediates the selective m...

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Bibliographic Details
Published in:Cilia (London) 2017-05, Vol.6 (1), p.8-8, Article 8
Main Authors: McClure-Begley, Tristan D, Klymkowsky, Michael W
Format: Article
Language:English
Subjects:
Cell cycle
Cellular proteins
Cilia
Cilia and ciliary motion
DNA repair
Gene expression
Genomes
Localization
Microscopy
Nuclear pores
Nuclear transport
Permeability
Proteins
Review
Studies
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Summary:Cilia appear to be derived, evolutionarily, from structures present in the ancestral (pre-ciliary) eukaryote, such as microtubule-based vesicle trafficking and chromosome segregation systems. Experimental observations suggest that the ciliary gate, the molecular complex that mediates the selective molecular movement between cytoplasmic and ciliary compartments, shares features with nuclear pores. Our hypothesis is that this shared transport machinery is at least partially responsible for the observation that a number of ciliary and ciliogenesis-associated proteins are found within nuclei where they play roles in the regulation of gene expression, DNA repair, and nuclear import and export. Recognizing the potential for such nuclear roles is critical when considering the phenotypic effects that arise from the mutational modification of ciliary proteins.
ISSN:2046-2530
2046-2530
DOI:10.1186/s13630-017-0052-x