PROTECTIVE ROLE OF CARNITINE SYNERGIZED WITH VITAMIN E AGAINST ISOPROTERENOL INDUCED CARDIAC INFARCTION IN RATS

Background: The current study aimed to evaluate the role of carnitine in combination with vitamin E in protection against myocardial infarction induced by isoproterenol (ISO) in rats. Materials and Methods: Rats were grouped into 5 (each 10 rats): Group I. Control fed a standard diet. Group III: Rat...

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Published in:African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2017, Vol.14 (2), p.25-32
Main Authors: Huwait, Etimad A, Ghamdi, Maryam A. Al
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Antioxidants - metabolism
Antioxidants - pharmacology
Antioxidants - therapeutic use
Cardiotonic Agents - adverse effects
Cardiotonic Agents - therapeutic use
carnitine
Carnitine - pharmacology
Carnitine - therapeutic use
Glutathione Peroxidase - metabolism
Glutathione Reductase - metabolism
Heart - drug effects
Inflammation - blood
Inflammation - etiology
Inflammation - prevention & control
ISO
Isoproterenol - adverse effects
Male
Malondialdehyde - blood
Myocardial infarction
Myocardial Infarction - chemically induced
Myocardial Infarction - metabolism
Myocardial Infarction - pathology
Myocardial Infarction - prevention & control
Myocardium - metabolism
Myocardium - pathology
Nitric Oxide - blood
Oxidative Stress - drug effects
Rats
Vitamin E
Vitamin E - pharmacology
Vitamin E - therapeutic use
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Summary:Background: The current study aimed to evaluate the role of carnitine in combination with vitamin E in protection against myocardial infarction induced by isoproterenol (ISO) in rats. Materials and Methods: Rats were grouped into 5 (each 10 rats): Group I. Control fed a standard diet. Group III: Rats were injected with vitamin E (100 IU/kg bw, i.p) daily. Group IV: Rats were given carnitine (20 mg/kg bw, i.p) daily .Group V: Rats were injected with both vitamin E (100 IU/kg bw, i.p) and carnitine (20 mg/kg bw, i.p) daily. On 7th, 8th, and 9th day, rats in groups (II-V) were injection i.p with ISO (55mg/kg b.w for successive three days). The treatment with carnitine and vitamin E were continuous for 21 days. Results: Canirine combined with vitamin E significantly increased coronary flow (CF) (P
ISSN:0189-6016
2505-0044
DOI:10.21010/ajtcam.v14i2.4