PERCH in Perspective: What Can It Teach Us About Pneumonia Etiology in Children?

The pneumonia team at the Bill & Melinda Gates Foundation congratulates the Pneumonia Etiology Research for Child Health (PERCH) study on delivering on their grant to collect high-quality data from thousands of children with World Health Organization–defined and very severe pneumonia and from co...

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Bibliographic Details
Published in:Clinical infectious diseases 2017-06, Vol.64 (suppl_3), p.S185-S187
Main Authors: Klugman, Keith P., Rodgers, Gail L.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Bacteria - drug effects
Bacteria - isolation & purification
Bacteria - pathogenicity
C-Reactive Protein - analysis
Child, Preschool
Developing Countries
Female
Haemophilus influenzae - isolation & purification
Haemophilus influenzae - pathogenicity
Humans
Infant
Male
Pneumonia - diagnosis
Pneumonia - etiology
Pneumonia - microbiology
Pneumonia - virology
Pneumonia, Bacterial - diagnosis
Pneumonia, Bacterial - drug therapy
Pneumonia, Bacterial - microbiology
Pneumonia, Viral - diagnosis
Pneumonia, Viral - virology
Sputum - microbiology
Sputum - virology
Supplement
World Health Organization
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Summary:The pneumonia team at the Bill & Melinda Gates Foundation congratulates the Pneumonia Etiology Research for Child Health (PERCH) study on delivering on their grant to collect high-quality data from thousands of children with World Health Organization–defined and very severe pneumonia and from controls in 9 diverse sites in 7 low- and middle-income countries. This supplement sets the foundation to understanding this complex study by providing an in-depth description of the study methodology, including discussion of key aspects such as antibiotic pretreatment, chest radiograph interpretation, utility of induced sputum in children, measurement of pathogen density, and use of C-reactive protein, and how these affect pneumonia etiology.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cix075