Obesity-Induced Hypertension: Brain Signaling Pathways

Obesity greatly increases the risk for cardiovascular, metabolic, and renal diseases and is one of the most significant and preventable causes of increased blood pressure (BP) in patients with essential hypertension. This review highlights recent advances in our understanding of central nervous syst...

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Bibliographic Details
Published in:Current hypertension reports 2016-07, Vol.18 (7), p.58-58, Article 58
Main Authors: do Carmo, Jussara M., da Silva, Alexandre A., Wang, Zhen, Fang, Taolin, Aberdein, Nicola, de Lara Rodriguez, Cecilia E. P., Hall, John E.
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
Cardiology
Central Nervous System - physiopathology
Family Medicine
General Practice
Humans
Hypertension
Hypertension - etiology
Hypertension - metabolism
Hypertension - physiopathology
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Nephrology
Obesity - complications
Primary Care Medicine
Secondary Hypertension: Nervous System Mechanisms (M Wyss
Section Editor
Signal Transduction
Sleep Apnea Syndromes - etiology
Topical Collection on Secondary Hypertension: Nervous System Mechanisms
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Summary:Obesity greatly increases the risk for cardiovascular, metabolic, and renal diseases and is one of the most significant and preventable causes of increased blood pressure (BP) in patients with essential hypertension. This review highlights recent advances in our understanding of central nervous system (CNS) signaling pathways that contribute to the etiology and pathogenesis of obesity-induced hypertension. We discuss the role of excess adiposity and activation of the brain leptin-melanocortin system in causing increased sympathetic activity in obesity. In addition, we highlight other potential brain mechanisms by which increased weight gain modulates metabolic and cardiovascular functions. Unraveling the CNS mechanisms responsible for increased sympathetic activation and hypertension and how circulating hormones activate brain signaling pathways to control BP offer potentially important therapeutic targets for obesity and hypertension.
ISSN:1522-6417
1534-3111
DOI:10.1007/s11906-016-0658-1