Role of germinal centers for the induction of broadly-reactive memory B cells

Highlights • Viral conserved domains are often concealed from the humoral responses. • Memory B cells counteract with viral mutations by germline-encoded cross-reactivity. • GC reactions fine-tune the specificity of memory B cells toward the conserved domains. • Permissive GC selection allows the fi...

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Bibliographic Details
Published in:Current opinion in immunology 2017-04, Vol.45, p.119-125
Main Authors: Takahashi, Yoshimasa, Kelsoe, Garnett
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antigens, Viral - immunology
B-Lymphocytes - immunology
Cell Proliferation
Cell Survival - immunology
Epitopes - immunology
Germinal Center - immunology
Germinal Center - virology
Humans
Immunologic Memory
Viruses - immunology
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Summary:Highlights • Viral conserved domains are often concealed from the humoral responses. • Memory B cells counteract with viral mutations by germline-encoded cross-reactivity. • GC reactions fine-tune the specificity of memory B cells toward the conserved domains. • Permissive GC selection allows the fine-tuning of memory specificity. • Broadly-reactive B cells may be recruited into the memory pool with an attenuated T-cell help.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2017.03.002