Emerging Evidence on Neutrophil Motility Supporting Its Usefulness to Define Vitamin C Intake Requirements

Establishing intake recommendations for vitamin C remains a challenge, as no suitable functional parameter has yet been agreed upon. In this report, we review the emerging evidence on neutrophil motility as a possible marker of vitamin C requirements and put the results in perspective with other app...

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Bibliographic Details
Published in:Nutrients 2017-05, Vol.9 (5), p.503
Main Authors: Elste, Volker, Troesch, Barbara, Eggersdorfer, Manfred, Weber, Peter
Format: Article
Language:English
Subjects:
Ascorbic acid
Ascorbic Acid - administration & dosage
Ascorbic Acid - blood
Ascorbic Acid - pharmacology
Biomarkers
Cardiovascular diseases
Cell Movement - physiology
Chemokinesis
Chemotaxis
Common cold
Functional anatomy
Humans
In vitro methods and tests
Intakes
Motility
Neutrophils
Nutritional Requirements
Vitamin C
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Summary:Establishing intake recommendations for vitamin C remains a challenge, as no suitable functional parameter has yet been agreed upon. In this report, we review the emerging evidence on neutrophil motility as a possible marker of vitamin C requirements and put the results in perspective with other approaches. A recent in vitro study showed that adequate levels of vitamin C were needed for this function to work optimally when measured as chemotaxis and chemokinesis. In a human study, neutrophil motility was optimal at intakes ≥250 mg/day. Interestingly, a Cochrane review showed a significant reduction in the duration of episodes of common cold with regular vitamin C intakes in a similar range. Additionally, it was shown that at a plasma level of 75 µmol/L, which is reached with vitamin C intakes ≥200 mg/day, incidences of cardiovascular disease were lowest. This evidence would suggest that daily intakes of 200 mg vitamin C might be advisable for the general adult population, which can be achieved by means of a diverse diet. However, additional studies are warranted to investigate the usefulness of neutrophil motility as a marker of vitamin C requirements.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu9050503