Quantitative hemodynamic PET imaging using image-derived arterial input function and a PET/MR hybrid scanner

Positron emission tomography (PET) with 15O-tracers is commonly used to measure brain hemodynamic parameters such as cerebral blood flow, cerebral blood volume, and cerebral metabolic rate of oxygen. Conventionally, the absolute quantification of these parameters requires an arterial input function...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2017-04, Vol.37 (4), p.1435-1446
Main Authors: Su, Yi, Vlassenko, Andrei G, Couture, Lars E, Benzinger, Tammie LS, Snyder, Abraham Z, Derdeyn, Colin P, Raichle, Marcus E
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brain - blood supply
Brain - diagnostic imaging
Cerebral Arteries - diagnostic imaging
Cerebral Arteries - physiology
Cerebrovascular Circulation - physiology
Cerebrovascular Disorders - diagnostic imaging
Female
Humans
Image Processing, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Male
Middle Aged
Original
Oxygen Radioisotopes
Positron Emission Tomography Computed Tomography - methods
Young Adult
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Summary:Positron emission tomography (PET) with 15O-tracers is commonly used to measure brain hemodynamic parameters such as cerebral blood flow, cerebral blood volume, and cerebral metabolic rate of oxygen. Conventionally, the absolute quantification of these parameters requires an arterial input function that is obtained invasively by sampling blood from an artery. In this work, we developed and validated an image-derived arterial input function technique that avoids the unreliable and burdensome arterial sampling procedure for full quantitative 15O-PET imaging. We then compared hemodynamic PET imaging performed on a PET/MR hybrid scanner against a conventional PET only scanner. We demonstrated the proposed imaging-based technique was able to generate brain hemodynamic parameter measurements in strong agreement with the traditional arterial sampling based approach. We also demonstrated that quantitative 15O-PET imaging can be successfully implemented on a PET/MR hybrid scanner.
ISSN:0271-678X
1559-7016
DOI:10.1177/0271678X16656200