HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma

Tonsillar squamous cell carcinomas (TSCCs) are the most common human papillomavirus- (HPV-) associated oropharyngeal cancers with poor prognosis. Homeodomain-interacting protein kinase 2 (HIPK2) is a central regulator of p53, which participates in apoptosis during the DNA damage response. HIPK2 is i...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-10
Main Authors: Cho, Seong Jin, Nam, Eun Sook, Kang, So Young, Kwon, Mi Jung, Rho, Young-Soo
Format: Article
Language:English
Subjects:
Aged
Alcohol
Analysis
Apoptosis
Biomarkers, Tumor - genetics
Cancer therapies
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - virology
Carrier Proteins - genetics
Cervical cancer
Chemotherapy
Development and progression
Disease-Free Survival
Female
Gene expression
Gene Expression Regulation, Neoplastic
Genetic aspects
Head & neck cancer
Health aspects
Hospitals
Human papillomavirus
Humans
Infections
Kinases
Male
Medical prognosis
Medical records
Medicine
Middle Aged
Otolaryngology
Papillomaviridae - genetics
Papillomaviridae - pathogenicity
Papillomavirus Infections - genetics
Papillomavirus Infections - virology
Papillomaviruses
Pathology
Phosphorylation
Prognosis
Protein expression
Protein kinases
Protein-Serine-Threonine Kinases - genetics
Proteins
Radiation therapy
RNA, Messenger - genetics
Signal transduction
Squamous cell carcinoma
Studies
Surgery
Throat cancer
Thyroid gland
Tonsillar Neoplasms - genetics
Tonsillar Neoplasms - pathology
Tonsillar Neoplasms - virology
Tumor Suppressor Protein p53 - genetics
Tumors
University colleges
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Summary:Tonsillar squamous cell carcinomas (TSCCs) are the most common human papillomavirus- (HPV-) associated oropharyngeal cancers with poor prognosis. Homeodomain-interacting protein kinase 2 (HIPK2) is a central regulator of p53, which participates in apoptosis during the DNA damage response. HIPK2 is involved in HPV-associated uterine cervical and cutaneous carcinogenesis through its binding of HPV E6, thereby preventing apoptosis and contributing to tumor progression. However, its clinical and prognostic significance in TSCC remains unclear. HIPK2 mRNA levels were analyzed in 20 normal tonsils and 20 TSCC specimens using real-time reverse transcription polymerase chain reaction. Immunohistochemistry of HIPK2 was performed in 79 resected specimens. HIPK2 was expressed in 57% of the TSCCs, and HIPK2 protein expression and HIPK2 mRNA levels were higher in TSCCs than in normal tonsils. HIPK2 overexpression was associated with poorly differentiated carcinoma and low alcohol consumption and was an independent prognostic factor for overall survival and disease-free survival (DFS) in TSCC and a negative independent prognostic factor for DFS in patients receiving postoperative radiotherapy. HIPK2 overexpression had a significant association with poorer DFS in HPV-positive TSCCs, but not in HPV-negative tumors. HIPK2 overexpression may be a potential prognostic marker for predicting prognoses and a high risk of recurrence, particularly in patients with HPV-positive TSCC.
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/1056427