Association of the long non-coding RNA MALAT1 with the polycomb repressive complex pathway in T and NK cell lymphoma

Recently, various long non-coding RNAs (lncRNAs) have been reported to have significant therapeutic or prognostic value. However, the expression of lncRNAs has not been investigated in T and NK cell lymphoma. Thus, we evaluated the biological and prognostic role of lncRNAs related to the polycomb re...

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Bibliographic Details
Published in:Oncotarget 2017-05, Vol.8 (19), p.31305-31317
Main Authors: Kim, Soo Hee, Kim, Se Hoon, Yang, Woo Ick, Kim, Soo Jeong, Yoon, Sun Och
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers
Bone Marrow - pathology
Cell Line, Tumor
Female
Gene Expression
Gene Knockdown Techniques
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Lymphoma, Extranodal NK-T-Cell - genetics
Lymphoma, Extranodal NK-T-Cell - metabolism
Lymphoma, Extranodal NK-T-Cell - mortality
Lymphoma, Extranodal NK-T-Cell - pathology
Male
Middle Aged
Neoplasm Staging
Polycomb-Group Proteins - metabolism
Prognosis
Research Paper
RNA, Long Noncoding - genetics
Signal Transduction
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Summary:Recently, various long non-coding RNAs (lncRNAs) have been reported to have significant therapeutic or prognostic value. However, the expression of lncRNAs has not been investigated in T and NK cell lymphoma. Thus, we evaluated the biological and prognostic role of lncRNAs related to the polycomb repressive complex (PRC) and PRC markers in tissue samples and cell lines of T and NK cell lymphoma. Among the tested lncRNAs, MALAT1 was most highly expressed in clinical samples and cell lines. High expression of MALAT1 as well as BMI1 was related to poor prognosis in patients with mature T cell lymphoma. In the tissue samples, BMI1 expression showed a positive correlation with EZH2, SUZ12, H3K27me3, and MALAT1. Multiple linear regression analysis showed that BMI1 expression was independently associated with H3K27me3. Direct binding of MALAT1 to the PRC2 components (EZH2 and SUZ12) was observed in a T cell lymphoma cell line; however, no direct binding of MALAT1 with H3K27me3 and BMI1 (a PRC1 component) was observed.In T and NK cell lymphomas, MALAT1 was related to poor prognosis. MALAT1 directly binds to EZH2 and SUZ12, and BMI1 activation may be induced possibly through H3K27me3.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.15453