11-oxygenated C19 steroids are the predominant androgens in polycystic ovary syndrome

Context:Androgen excess is a defining feature of polycystic ovary syndrome (PCOS) but the exact origin of hyperandrogenemia remains a matter of debate. Recent studies have highlighted the importance of the 11-oxygenated C19 steroid pathway to androgen metabolism in humans. In this study, we analyzed...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2017-03, Vol.102 (3), p.840-848
Main Authors: O’Reilly, Michael W, Kempegowda, Punith, Jenkinson, Carl, Taylor, Angela E, Quanson, Jonathan L, Storbeck, Karl-Heinz, Arlt, Wiebke
Format: Article
Language:English
Subjects:
Adult
Androgens
Androgens - metabolism
Androstenedione
Androstenedione - analogs & derivatives
Androstenedione - metabolism
Androstenes - metabolism
Blood Glucose - metabolism
Body mass
Body mass index
Case-Control Studies
Chromatography
Chromatography, Liquid
Clinical s
Dehydroepiandrosterone
Dehydroepiandrosterone - metabolism
Demographics
Excretion
Female
Gas chromatography
Gas Chromatography-Mass Spectrometry
Humans
Hydroxytestosterones - metabolism
Hyperandrogenism - complications
Hyperandrogenism - metabolism
Insulin
Insulin - metabolism
Insulin Resistance
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Metabolism
Obesity - complications
Obesity - metabolism
Oxygenation
Polycystic ovary syndrome
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - metabolism
Scientific imaging
Steroid hormones
Steroids
Tandem Mass Spectrometry
Testosterone
Testosterone - analogs & derivatives
Testosterone - metabolism
Young Adult
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Summary:Context:Androgen excess is a defining feature of polycystic ovary syndrome (PCOS) but the exact origin of hyperandrogenemia remains a matter of debate. Recent studies have highlighted the importance of the 11-oxygenated C19 steroid pathway to androgen metabolism in humans. In this study, we analyzed the contribution of 11-oxygenated androgens to the androgen excess phenotype in women with PCOS.Methods:114 women with PCOS and 49 healthy controls underwent measurement of serum androgens by liquid chromatography-tandem mass spectrometry. 24-h urinary androgen excretion was analyzed by gas chromatography-mass spectrometry. Fasting plasma insulin and glucose were measured for calculation of homeostatic model assessment of insulin resistance (HOMA-IR). Baseline demographic data including body mass index were recorded.Results:As expected, serum concentrations of the classic androgens testosterone (p
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2016-3285