Reduced Transforming Growth Factor-β Activity in the Endometrium of Women With Heavy Menstrual Bleeding

Abstract Context: Heavy menstrual bleeding (HMB) is common and incapacitating. Aberrant menstrual endometrial repair may result in HMB. The transforming growth factor (TGF)-β superfamily contributes to tissue repair, but its role in HMB is unknown. Objective: We hypothesized that TGF-β1 is important...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2017-04, Vol.102 (4), p.1299-1308
Main Authors: Maybin, Jacqueline A., Boswell, Lyndsey, Young, Vicky J., Duncan, William C., Critchley, Hilary O. D.
Format: Article
Language:English
Subjects:
Adult
Cells, Cultured
Clinical s
Endometrium - metabolism
Endometrium - pathology
Female
Humans
Menstrual Cycle - physiology
Menstruation - genetics
Menstruation - metabolism
Menstruation Disturbances - genetics
Menstruation Disturbances - metabolism
Menstruation Disturbances - pathology
Middle Aged
Transforming Growth Factor beta - genetics
Transforming Growth Factor beta - metabolism
Young Adult
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Summary:Abstract Context: Heavy menstrual bleeding (HMB) is common and incapacitating. Aberrant menstrual endometrial repair may result in HMB. The transforming growth factor (TGF)-β superfamily contributes to tissue repair, but its role in HMB is unknown. Objective: We hypothesized that TGF-β1 is important for endometrial repair, and women with HMB have aberrant TGF-β1 activity at menses. Participants/Setting: Endometrial biopsies were collected from women, and menstrual blood loss objectively measured [HMB >80 mL/cycle; normal menstrual bleeding (NMB)
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2016-3437