Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies

Objective To map the diverse health outcomes associated with serum uric acid (SUA) levels.Design Umbrella review.Data sources Medline, Embase, Cochrane Database of Systematic Reviews, and screening of citations and references.Eligibility criteria Systematic reviews and meta-analyses of observational...

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Bibliographic Details
Published in:BMJ (Online) 2017-06, Vol.357, p.j2376
Main Authors: Li, Xue, Meng, Xiangrui, Timofeeva, Maria, Tzoulaki, Ioanna, Tsilidis, Konstantinos K, Ioannidis, P A, Campbell, Harry, Theodoratou, Evropi
Format: Article
Language:English
Subjects:
Bias
Biomarkers
Biomarkers - blood
Causality
Confidence intervals
Gout - blood
Humans
Intervention
Mendelian Randomization Analysis
Meta-analysis
Metabolic syndrome
Nephrolithiasis - blood
Observational studies
Observational Studies as Topic
Oxidative stress
Randomized Controlled Trials as Topic
Rheumatism
Uric acid
Uric Acid - blood
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Summary:Objective To map the diverse health outcomes associated with serum uric acid (SUA) levels.Design Umbrella review.Data sources Medline, Embase, Cochrane Database of Systematic Reviews, and screening of citations and references.Eligibility criteria Systematic reviews and meta-analyses of observational studies that examined associations between SUA level and health outcomes, meta-analyses of randomised controlled trials that investigated health outcomes related to SUA lowering treatment, and Mendelian randomisation studies that explored the causal associations of SUA level with health outcomes.Results 57 articles reporting 15 systematic reviews and144 meta-analyses of observational studies (76 unique outcomes), 8 articles reporting 31 meta-analyses of randomised controlled trials (20 unique outcomes), and 36 articles reporting 107 Mendelian randomisation studies (56 unique outcomes) met the eligibility criteria. Across all three study types, 136 unique health outcomes were reported. 16 unique outcomes in meta-analyses of observational studies had P
ISSN:0959-8138
1756-1833
1756-1833
DOI:10.1136/bmj.j2376