The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

Astrocytes are the most populous glial subtype and are critical for brain function. Despite this, historically there have been few studies into the role that they may have in neurodegenerative diseases, such as Parkinson’s disease (PD). Recently, however, several studies have determined that genes k...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2017-06, Vol.40 (6), p.358-370
Main Authors: Booth, Heather D.E, Hirst, Warren D, Wade-Martins, Richard
Format: Article
Language:English
Subjects:
Animals
Astrocytes - physiology
Humans
Neurology
Parkinson Disease - physiopathology
Review
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Summary:Astrocytes are the most populous glial subtype and are critical for brain function. Despite this, historically there have been few studies into the role that they may have in neurodegenerative diseases, such as Parkinson’s disease (PD). Recently, however, several studies have determined that genes known to have a causative role in the development of PD are expressed in astrocytes and have important roles in astrocyte function. Here, we review these recent developments and discuss their impact on our understanding of the pathophysiology of PD, and the implications that this might have for its treatment.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2017.04.001