Polymorphisms of lipid metabolism enzyme-coding genes in patients with diabetic dyslipidemia

The polymorphisms/mutations of genes encoding proteins and enzymes involved in lipoprotein metabolism play important roles in the development of diabetic dyslipidemia. The aim of our study was to investigate the effects of LPL (rs320), LIPC (rs2070895), SCARB1 (rs5888), LCAT (rs2292318), CETP (rs708...

Full description

Saved in:
Bibliographic Details
Published in:Anatolian journal of cardiology 2017-04, Vol.17 (4), p.313-321
Main Authors: Tetik Vardarlı, Aslı, Harman, Ece, Bozok Çetintaş, Vildan, Kayıkçıoğlu, Meral, Vardarlı, Egemen, Zengi, Ayhan, Küçükaslan, Ali Şahin, Eroğlu, Zuhal
Format: Article
Language:English
Subjects:
Diabetes
Metabolic disorders
Metabolism
Original Investigation
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The polymorphisms/mutations of genes encoding proteins and enzymes involved in lipoprotein metabolism play important roles in the development of diabetic dyslipidemia. The aim of our study was to investigate the effects of LPL (rs320), LIPC (rs2070895), SCARB1 (rs5888), LCAT (rs2292318), CETP (rs708272), ADIPOQ (rs1501299), RETN (rs3745367), PON1 (rs662), and MNSOD (rs4880) gene polymorphisms on lipid metabolism and diabetic dyslipidemia. This case-control study included 217 patients with diabetic dyslipidemia and 212 healthy age- and gender-matched individuals. Genomic DNA isolation was performed from blood samples, and genotype analysis was performed using melting curve analysis on a LightCycler® 480 Instrument. The chi-square test was used to compare genotype distribution and allele frequencies between the groups. Significant associations were observed between LPL (rs320) (p
ISSN:2149-2263
2149-2271
DOI:10.14744/AnatolJCardiol.2016.7142