Loading…

Effect of Moderate-Intensity Exercise Training on Peak Oxygen Consumption in Patients With Hypertrophic Cardiomyopathy: A Randomized Clinical Trial

IMPORTANCE: Formulating exercise recommendations for patients with hypertrophic cardiomyopathy is challenging because of concern about triggering ventricular arrhythmias and because a clinical benefit has not been previously established in this population. OBJECTIVE: To determine whether moderate-in...

Full description

Saved in:
Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2017-04, Vol.317 (13), p.1349-1357
Main Authors: Saberi, Sara, Wheeler, Matthew, Bragg-Gresham, Jennifer, Hornsby, Whitney, Agarwal, Prachi P, Attili, Anil, Concannon, Maryann, Dries, Annika M, Shmargad, Yael, Salisbury, Heidi, Kumar, Suwen, Herrera, Jonathan J, Myers, Jonathan, Helms, Adam S, Ashley, Euan A, Day, Sharlene M
Format: Article
Language:English
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 1357
container_issue 13
container_start_page 1349
container_title JAMA : the journal of the American Medical Association
container_volume 317
creator Saberi, Sara
Wheeler, Matthew
Bragg-Gresham, Jennifer
Hornsby, Whitney
Agarwal, Prachi P
Attili, Anil
Concannon, Maryann
Dries, Annika M
Shmargad, Yael
Salisbury, Heidi
Kumar, Suwen
Herrera, Jonathan J
Myers, Jonathan
Helms, Adam S
Ashley, Euan A
Day, Sharlene M
description IMPORTANCE: Formulating exercise recommendations for patients with hypertrophic cardiomyopathy is challenging because of concern about triggering ventricular arrhythmias and because a clinical benefit has not been previously established in this population. OBJECTIVE: To determine whether moderate-intensity exercise training improves exercise capacity in adults with hypertrophic cardiomyopathy. DESIGN, SETTING, AND PARTICIPANTS: A randomized clinical trial involving 136 patients with hypertrophic cardiomyopathy was conducted between April 2010 and October 2015 at 2 academic medical centers in the United States (University of Michigan Health System and Stanford University Medical Center). Date of last follow-up was November 2016. INTERVENTIONS: Participants were randomly assigned to 16 weeks of moderate-intensity exercise training (n = 67) or usual activity (n = 69). MAIN OUTCOMES AND MEASURES: The primary outcome measure was change in peak oxygen consumption from baseline to 16 weeks. RESULTS: Among the 136 randomized participants (mean age, 50.4 [SD, 13.3] years; 42% women), 113 (83%) completed the study. At 16 weeks, the change in mean peak oxygen consumption was +1.35 (95% CI, 0.50 to 2.21) mL/kg/min among participants in the exercise training group and +0.08 (95% CI, −0.62 to 0.79) mL/kg/min among participants in the usual-activity group (between-group difference, 1.27 [95% CI, 0.17 to 2.37]; P = .02). There were no occurrences of sustained ventricular arrhythmia, sudden cardiac arrest, appropriate defibrillator shock, or death in either group. CONCLUSIONS AND RELEVANCE: In this preliminary study involving patients with hypertrophic cardiomyopathy, moderate-intensity exercise compared with usual activity resulted in a statistically significant but small increase in exercise capacity at 16 weeks. Further research is needed to understand the clinical importance of this finding in patients with hypertrophic cardiomyopathy, as well as the long-term safety of exercise at moderate and higher levels of intensity. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01127061
doi_str_mv 10.1001/jama.2017.2503
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5469299</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ama_id>2612591</ama_id><sourcerecordid>1897381629</sourcerecordid><originalsourceid>FETCH-LOGICAL-a385t-da0b26c8cc1e5b6f0d926c543b4047ca41492cbacb3f370903c7e655fe58778e3</originalsourceid><addsrcrecordid>eNqNkkFv1DAQhSMEotvClQMHZIkLlyx2HMcOB6RqtdBKRUWoiKPlOJNdL4md2l7U9G_wh3G0ZQWc8MWy3zdvxtbLshcELwnG5O1ODWpZYMKXBcP0UbYgjIqcslo8zhYY1yLnpShPstMQdjgtQvnT7KQQFFec8UX2c911oCNyHfrkWvAqQn5pI9hg4oTWd-C1CYBuvDLW2A1yFn0G9R1d300bsGjlbNgPYzTp3iRJRQM2BvTNxC26mEbw0btxazRaKd8aN0xuVHE7vUPn6IuyrRvMPbRo1Sd3rfrUx6j-WfakU32A5w_7Wfb1w_pmdZFfXX-8XJ1f5YoKFvNW4aaotNCaAGuqDrd1OrKSNiUuuVYlKetCN0o3tKMc15hqDhVjHTDBuQB6lr0_-I77ZoBWp8m96uXozaD8JJ0y8m_Fmq3cuB-SlVVd1HUyePNg4N3tHkKUgwka-l5ZcPsgiag5FaQq_gflQhQlKUhCX_-D7tze2_QTsyEhyY-UiVoeKO1dCB6649wEyzkaco6GnKMh52ikgld_vvaI_85CAl4egLnuqFakYDWhvwCji7_z</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1891116214</pqid></control><display><type>article</type><title>Effect of Moderate-Intensity Exercise Training on Peak Oxygen Consumption in Patients With Hypertrophic Cardiomyopathy: A Randomized Clinical Trial</title><source>JAMA</source><creator>Saberi, Sara ; Wheeler, Matthew ; Bragg-Gresham, Jennifer ; Hornsby, Whitney ; Agarwal, Prachi P ; Attili, Anil ; Concannon, Maryann ; Dries, Annika M ; Shmargad, Yael ; Salisbury, Heidi ; Kumar, Suwen ; Herrera, Jonathan J ; Myers, Jonathan ; Helms, Adam S ; Ashley, Euan A ; Day, Sharlene M</creator><creatorcontrib>Saberi, Sara ; Wheeler, Matthew ; Bragg-Gresham, Jennifer ; Hornsby, Whitney ; Agarwal, Prachi P ; Attili, Anil ; Concannon, Maryann ; Dries, Annika M ; Shmargad, Yael ; Salisbury, Heidi ; Kumar, Suwen ; Herrera, Jonathan J ; Myers, Jonathan ; Helms, Adam S ; Ashley, Euan A ; Day, Sharlene M</creatorcontrib><description>IMPORTANCE: Formulating exercise recommendations for patients with hypertrophic cardiomyopathy is challenging because of concern about triggering ventricular arrhythmias and because a clinical benefit has not been previously established in this population. OBJECTIVE: To determine whether moderate-intensity exercise training improves exercise capacity in adults with hypertrophic cardiomyopathy. DESIGN, SETTING, AND PARTICIPANTS: A randomized clinical trial involving 136 patients with hypertrophic cardiomyopathy was conducted between April 2010 and October 2015 at 2 academic medical centers in the United States (University of Michigan Health System and Stanford University Medical Center). Date of last follow-up was November 2016. INTERVENTIONS: Participants were randomly assigned to 16 weeks of moderate-intensity exercise training (n = 67) or usual activity (n = 69). MAIN OUTCOMES AND MEASURES: The primary outcome measure was change in peak oxygen consumption from baseline to 16 weeks. RESULTS: Among the 136 randomized participants (mean age, 50.4 [SD, 13.3] years; 42% women), 113 (83%) completed the study. At 16 weeks, the change in mean peak oxygen consumption was +1.35 (95% CI, 0.50 to 2.21) mL/kg/min among participants in the exercise training group and +0.08 (95% CI, −0.62 to 0.79) mL/kg/min among participants in the usual-activity group (between-group difference, 1.27 [95% CI, 0.17 to 2.37]; P = .02). There were no occurrences of sustained ventricular arrhythmia, sudden cardiac arrest, appropriate defibrillator shock, or death in either group. CONCLUSIONS AND RELEVANCE: In this preliminary study involving patients with hypertrophic cardiomyopathy, moderate-intensity exercise compared with usual activity resulted in a statistically significant but small increase in exercise capacity at 16 weeks. Further research is needed to understand the clinical importance of this finding in patients with hypertrophic cardiomyopathy, as well as the long-term safety of exercise at moderate and higher levels of intensity. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01127061</description><identifier>ISSN: 0098-7484</identifier><identifier>EISSN: 1538-3598</identifier><identifier>DOI: 10.1001/jama.2017.2503</identifier><identifier>PMID: 28306757</identifier><identifier>CODEN: JAMAAP</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Adult ; Adults ; Arrhythmias, Cardiac ; Cardiomyopathy ; Cardiomyopathy, Hypertrophic - physiopathology ; Cardiomyopathy, Hypertrophic - rehabilitation ; Clinical trials ; Death, Sudden, Cardiac ; Exercise ; Exercise Therapy - methods ; Female ; Humans ; Middle Aged ; Online First ; Oxygen ; Oxygen Consumption ; Physical Endurance ; Preliminary Communication</subject><ispartof>JAMA : the journal of the American Medical Association, 2017-04, Vol.317 (13), p.1349-1357</ispartof><rights>Copyright American Medical Association Apr 4, 2017</rights><rights>Copyright 2017 American Medical Association. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28306757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saberi, Sara</creatorcontrib><creatorcontrib>Wheeler, Matthew</creatorcontrib><creatorcontrib>Bragg-Gresham, Jennifer</creatorcontrib><creatorcontrib>Hornsby, Whitney</creatorcontrib><creatorcontrib>Agarwal, Prachi P</creatorcontrib><creatorcontrib>Attili, Anil</creatorcontrib><creatorcontrib>Concannon, Maryann</creatorcontrib><creatorcontrib>Dries, Annika M</creatorcontrib><creatorcontrib>Shmargad, Yael</creatorcontrib><creatorcontrib>Salisbury, Heidi</creatorcontrib><creatorcontrib>Kumar, Suwen</creatorcontrib><creatorcontrib>Herrera, Jonathan J</creatorcontrib><creatorcontrib>Myers, Jonathan</creatorcontrib><creatorcontrib>Helms, Adam S</creatorcontrib><creatorcontrib>Ashley, Euan A</creatorcontrib><creatorcontrib>Day, Sharlene M</creatorcontrib><title>Effect of Moderate-Intensity Exercise Training on Peak Oxygen Consumption in Patients With Hypertrophic Cardiomyopathy: A Randomized Clinical Trial</title><title>JAMA : the journal of the American Medical Association</title><addtitle>JAMA</addtitle><description>IMPORTANCE: Formulating exercise recommendations for patients with hypertrophic cardiomyopathy is challenging because of concern about triggering ventricular arrhythmias and because a clinical benefit has not been previously established in this population. OBJECTIVE: To determine whether moderate-intensity exercise training improves exercise capacity in adults with hypertrophic cardiomyopathy. DESIGN, SETTING, AND PARTICIPANTS: A randomized clinical trial involving 136 patients with hypertrophic cardiomyopathy was conducted between April 2010 and October 2015 at 2 academic medical centers in the United States (University of Michigan Health System and Stanford University Medical Center). Date of last follow-up was November 2016. INTERVENTIONS: Participants were randomly assigned to 16 weeks of moderate-intensity exercise training (n = 67) or usual activity (n = 69). MAIN OUTCOMES AND MEASURES: The primary outcome measure was change in peak oxygen consumption from baseline to 16 weeks. RESULTS: Among the 136 randomized participants (mean age, 50.4 [SD, 13.3] years; 42% women), 113 (83%) completed the study. At 16 weeks, the change in mean peak oxygen consumption was +1.35 (95% CI, 0.50 to 2.21) mL/kg/min among participants in the exercise training group and +0.08 (95% CI, −0.62 to 0.79) mL/kg/min among participants in the usual-activity group (between-group difference, 1.27 [95% CI, 0.17 to 2.37]; P = .02). There were no occurrences of sustained ventricular arrhythmia, sudden cardiac arrest, appropriate defibrillator shock, or death in either group. CONCLUSIONS AND RELEVANCE: In this preliminary study involving patients with hypertrophic cardiomyopathy, moderate-intensity exercise compared with usual activity resulted in a statistically significant but small increase in exercise capacity at 16 weeks. Further research is needed to understand the clinical importance of this finding in patients with hypertrophic cardiomyopathy, as well as the long-term safety of exercise at moderate and higher levels of intensity. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01127061</description><subject>Adult</subject><subject>Adults</subject><subject>Arrhythmias, Cardiac</subject><subject>Cardiomyopathy</subject><subject>Cardiomyopathy, Hypertrophic - physiopathology</subject><subject>Cardiomyopathy, Hypertrophic - rehabilitation</subject><subject>Clinical trials</subject><subject>Death, Sudden, Cardiac</subject><subject>Exercise</subject><subject>Exercise Therapy - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Online First</subject><subject>Oxygen</subject><subject>Oxygen Consumption</subject><subject>Physical Endurance</subject><subject>Preliminary Communication</subject><issn>0098-7484</issn><issn>1538-3598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkkFv1DAQhSMEotvClQMHZIkLlyx2HMcOB6RqtdBKRUWoiKPlOJNdL4md2l7U9G_wh3G0ZQWc8MWy3zdvxtbLshcELwnG5O1ODWpZYMKXBcP0UbYgjIqcslo8zhYY1yLnpShPstMQdjgtQvnT7KQQFFec8UX2c911oCNyHfrkWvAqQn5pI9hg4oTWd-C1CYBuvDLW2A1yFn0G9R1d300bsGjlbNgPYzTp3iRJRQM2BvTNxC26mEbw0btxazRaKd8aN0xuVHE7vUPn6IuyrRvMPbRo1Sd3rfrUx6j-WfakU32A5w_7Wfb1w_pmdZFfXX-8XJ1f5YoKFvNW4aaotNCaAGuqDrd1OrKSNiUuuVYlKetCN0o3tKMc15hqDhVjHTDBuQB6lr0_-I77ZoBWp8m96uXozaD8JJ0y8m_Fmq3cuB-SlVVd1HUyePNg4N3tHkKUgwka-l5ZcPsgiag5FaQq_gflQhQlKUhCX_-D7tze2_QTsyEhyY-UiVoeKO1dCB6649wEyzkaco6GnKMh52ikgld_vvaI_85CAl4egLnuqFakYDWhvwCji7_z</recordid><startdate>20170404</startdate><enddate>20170404</enddate><creator>Saberi, Sara</creator><creator>Wheeler, Matthew</creator><creator>Bragg-Gresham, Jennifer</creator><creator>Hornsby, Whitney</creator><creator>Agarwal, Prachi P</creator><creator>Attili, Anil</creator><creator>Concannon, Maryann</creator><creator>Dries, Annika M</creator><creator>Shmargad, Yael</creator><creator>Salisbury, Heidi</creator><creator>Kumar, Suwen</creator><creator>Herrera, Jonathan J</creator><creator>Myers, Jonathan</creator><creator>Helms, Adam S</creator><creator>Ashley, Euan A</creator><creator>Day, Sharlene M</creator><general>American Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170404</creationdate><title>Effect of Moderate-Intensity Exercise Training on Peak Oxygen Consumption in Patients With Hypertrophic Cardiomyopathy: A Randomized Clinical Trial</title><author>Saberi, Sara ; Wheeler, Matthew ; Bragg-Gresham, Jennifer ; Hornsby, Whitney ; Agarwal, Prachi P ; Attili, Anil ; Concannon, Maryann ; Dries, Annika M ; Shmargad, Yael ; Salisbury, Heidi ; Kumar, Suwen ; Herrera, Jonathan J ; Myers, Jonathan ; Helms, Adam S ; Ashley, Euan A ; Day, Sharlene M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a385t-da0b26c8cc1e5b6f0d926c543b4047ca41492cbacb3f370903c7e655fe58778e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Arrhythmias, Cardiac</topic><topic>Cardiomyopathy</topic><topic>Cardiomyopathy, Hypertrophic - physiopathology</topic><topic>Cardiomyopathy, Hypertrophic - rehabilitation</topic><topic>Clinical trials</topic><topic>Death, Sudden, Cardiac</topic><topic>Exercise</topic><topic>Exercise Therapy - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Online First</topic><topic>Oxygen</topic><topic>Oxygen Consumption</topic><topic>Physical Endurance</topic><topic>Preliminary Communication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saberi, Sara</creatorcontrib><creatorcontrib>Wheeler, Matthew</creatorcontrib><creatorcontrib>Bragg-Gresham, Jennifer</creatorcontrib><creatorcontrib>Hornsby, Whitney</creatorcontrib><creatorcontrib>Agarwal, Prachi P</creatorcontrib><creatorcontrib>Attili, Anil</creatorcontrib><creatorcontrib>Concannon, Maryann</creatorcontrib><creatorcontrib>Dries, Annika M</creatorcontrib><creatorcontrib>Shmargad, Yael</creatorcontrib><creatorcontrib>Salisbury, Heidi</creatorcontrib><creatorcontrib>Kumar, Suwen</creatorcontrib><creatorcontrib>Herrera, Jonathan J</creatorcontrib><creatorcontrib>Myers, Jonathan</creatorcontrib><creatorcontrib>Helms, Adam S</creatorcontrib><creatorcontrib>Ashley, Euan A</creatorcontrib><creatorcontrib>Day, Sharlene M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JAMA : the journal of the American Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saberi, Sara</au><au>Wheeler, Matthew</au><au>Bragg-Gresham, Jennifer</au><au>Hornsby, Whitney</au><au>Agarwal, Prachi P</au><au>Attili, Anil</au><au>Concannon, Maryann</au><au>Dries, Annika M</au><au>Shmargad, Yael</au><au>Salisbury, Heidi</au><au>Kumar, Suwen</au><au>Herrera, Jonathan J</au><au>Myers, Jonathan</au><au>Helms, Adam S</au><au>Ashley, Euan A</au><au>Day, Sharlene M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Moderate-Intensity Exercise Training on Peak Oxygen Consumption in Patients With Hypertrophic Cardiomyopathy: A Randomized Clinical Trial</atitle><jtitle>JAMA : the journal of the American Medical Association</jtitle><addtitle>JAMA</addtitle><date>2017-04-04</date><risdate>2017</risdate><volume>317</volume><issue>13</issue><spage>1349</spage><epage>1357</epage><pages>1349-1357</pages><issn>0098-7484</issn><eissn>1538-3598</eissn><coden>JAMAAP</coden><abstract>IMPORTANCE: Formulating exercise recommendations for patients with hypertrophic cardiomyopathy is challenging because of concern about triggering ventricular arrhythmias and because a clinical benefit has not been previously established in this population. OBJECTIVE: To determine whether moderate-intensity exercise training improves exercise capacity in adults with hypertrophic cardiomyopathy. DESIGN, SETTING, AND PARTICIPANTS: A randomized clinical trial involving 136 patients with hypertrophic cardiomyopathy was conducted between April 2010 and October 2015 at 2 academic medical centers in the United States (University of Michigan Health System and Stanford University Medical Center). Date of last follow-up was November 2016. INTERVENTIONS: Participants were randomly assigned to 16 weeks of moderate-intensity exercise training (n = 67) or usual activity (n = 69). MAIN OUTCOMES AND MEASURES: The primary outcome measure was change in peak oxygen consumption from baseline to 16 weeks. RESULTS: Among the 136 randomized participants (mean age, 50.4 [SD, 13.3] years; 42% women), 113 (83%) completed the study. At 16 weeks, the change in mean peak oxygen consumption was +1.35 (95% CI, 0.50 to 2.21) mL/kg/min among participants in the exercise training group and +0.08 (95% CI, −0.62 to 0.79) mL/kg/min among participants in the usual-activity group (between-group difference, 1.27 [95% CI, 0.17 to 2.37]; P = .02). There were no occurrences of sustained ventricular arrhythmia, sudden cardiac arrest, appropriate defibrillator shock, or death in either group. CONCLUSIONS AND RELEVANCE: In this preliminary study involving patients with hypertrophic cardiomyopathy, moderate-intensity exercise compared with usual activity resulted in a statistically significant but small increase in exercise capacity at 16 weeks. Further research is needed to understand the clinical importance of this finding in patients with hypertrophic cardiomyopathy, as well as the long-term safety of exercise at moderate and higher levels of intensity. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01127061</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>28306757</pmid><doi>10.1001/jama.2017.2503</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0098-7484
ispartof JAMA : the journal of the American Medical Association, 2017-04, Vol.317 (13), p.1349-1357
issn 0098-7484
1538-3598
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5469299
source JAMA
subjects Adult
Adults
Arrhythmias, Cardiac
Cardiomyopathy
Cardiomyopathy, Hypertrophic - physiopathology
Cardiomyopathy, Hypertrophic - rehabilitation
Clinical trials
Death, Sudden, Cardiac
Exercise
Exercise Therapy - methods
Female
Humans
Middle Aged
Online First
Oxygen
Oxygen Consumption
Physical Endurance
Preliminary Communication
title Effect of Moderate-Intensity Exercise Training on Peak Oxygen Consumption in Patients With Hypertrophic Cardiomyopathy: A Randomized Clinical Trial
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A27%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Moderate-Intensity%20Exercise%20Training%20on%20Peak%20Oxygen%20Consumption%20in%20Patients%20With%20Hypertrophic%20Cardiomyopathy:%20A%20Randomized%20Clinical%20Trial&rft.jtitle=JAMA%20:%20the%20journal%20of%20the%20American%20Medical%20Association&rft.au=Saberi,%20Sara&rft.date=2017-04-04&rft.volume=317&rft.issue=13&rft.spage=1349&rft.epage=1357&rft.pages=1349-1357&rft.issn=0098-7484&rft.eissn=1538-3598&rft.coden=JAMAAP&rft_id=info:doi/10.1001/jama.2017.2503&rft_dat=%3Cproquest_pubme%3E1897381629%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a385t-da0b26c8cc1e5b6f0d926c543b4047ca41492cbacb3f370903c7e655fe58778e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1891116214&rft_id=info:pmid/28306757&rfr_iscdi=true