Plasmodium falciparum Merozoite Surface Protein 6 Displays Multiple Targets for Naturally Occurring Antibodies That Mediate Monocyte-Dependent Parasite Killing

Plasmodium falciparum MSP6 is a merozoite surface antigen that shows organization and sequence homologies similar to those of MSP3. Within its C-terminus conserved region, it presents some epitopes that are cross-reactive with MSP3 and others that are not, both being targets of naturally occurring a...

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Bibliographic Details
Published in:Infection and Immunity 2005-02, Vol.73 (2), p.1235-1238
Main Authors: Singh, Subhash, Soe, Soe, Roussilhon, Christian, Corradin, Giampietro, Druilhe, Pierre
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antibodies - immunology
Antigens, Protozoan - immunology
Biological and medical sciences
Epitopes - immunology
Fundamental and applied biological sciences. Psychology
Fungal and Parasitic Infections
Humans
Malaria, Falciparum - immunology
Membrane Proteins - immunology
Microbiology
Molecular Sequence Data
Monocytes - immunology
Plasmodium falciparum
Plasmodium falciparum - immunology
Protozoan Proteins - immunology
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Description
Summary:Plasmodium falciparum MSP6 is a merozoite surface antigen that shows organization and sequence homologies similar to those of MSP3. Within its C-terminus conserved region, it presents some epitopes that are cross-reactive with MSP3 and others that are not, both being targets of naturally occurring antibodies that block the P. falciparum erythrocytic cycle in cooperation with monocytes.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.73.2.1235-1238.2005