Systemic inflammation response index (SIRI) predicts prognosis in hepatocellular carcinoma patients

The systemic inflammation response index (SIRI) is a useful tool for predicting prognosis in some types of cancer. In this retrospective study, we evaluated the efficacy of SIRI in predicting overall survival in hepatocellular carcinoma (HCC) patients following local or systemic therapy. A cutoff va...

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Bibliographic Details
Published in:Oncotarget 2017-05, Vol.8 (21), p.34954-34960
Main Authors: Xu, Litao, Yu, Shulin, Zhuang, Liping, Wang, Peng, Shen, Yehua, Lin, Junhua, Meng, Zhiqiang
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Hepatocellular - immunology
Carcinoma, Hepatocellular - pathology
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Liver Neoplasms - immunology
Liver Neoplasms - pathology
Male
Middle Aged
Neoplasm Staging
Prognosis
Research Paper
Retrospective Studies
ROC Curve
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Summary:The systemic inflammation response index (SIRI) is a useful tool for predicting prognosis in some types of cancer. In this retrospective study, we evaluated the efficacy of SIRI in predicting overall survival in hepatocellular carcinoma (HCC) patients following local or systemic therapy. A cutoff value of 1.05 was identified for SIRI using ROC analysis in a training patient cohort. In the validation cohort, survival analysis revealed that median overall survival was longer in HCC patients with SIRI scores < 1.05 than in those with scores ≥ 1.05. Cox analysis of the validation cohort demonstrated that SIRI was associated with overall survival and was more predictive of overall survival that the AFP level or Child-Pugh score. However, SIRI and Barcelona Clinic Liver Cancer (BCLC) stage were equally effective for predicting survival. In addition, HCC patients with BCLC stage C had higher SIRI scores and poorer overall survival. SIRI also correlated with liver function parameters. Thus SIRI may be a convenient, low cost and reliable tumor marker for predicting prognosis in HCC patients.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.16865