Non-lamellar lipid assembly at interfaces: controlling layer structure by responsive nanogel particles

Biological membranes do not only occur as planar bilayer structures, but depending on the lipid composition, can also curve into intriguing three-dimensional structures. In order to fully understand the biological implications as well as to reveal the full potential for applications, e.g. for drug d...

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Bibliographic Details
Published in:Interface focus 2017-08, Vol.7 (4), p.20160150-20160150
Main Authors: Dabkowska, Aleksandra P., Valldeperas, Maria, Hirst, Christopher, Montis, Costanza, Pálsson, Gunnar K., Wang, Meina, Nöjd, Sofi, Gentile, Luigi, Barauskas, Justas, Steinke, Nina-Juliane, Schroeder-Turk, Gerd E., George, Sebastian, Skoda, Maximilian W. A., Nylander, Tommy
Format: Article
Language:English
Subjects:
Chemical Sciences
Cubic Bicontinuous Phases
Fysikalisk kemi
Kemi
Lipid Non-Lamellar Liquid Crystalline
Microgel
Nanogel
Natural Sciences
Naturvetenskap
Neutron Reflectivity
Physical Chemistry
Polymer Chemistry
Polymerkemi
Responsive Lipid Layers
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Summary:Biological membranes do not only occur as planar bilayer structures, but depending on the lipid composition, can also curve into intriguing three-dimensional structures. In order to fully understand the biological implications as well as to reveal the full potential for applications, e.g. for drug delivery and other biomedical devices, of such structures, well-defined model systems are required. Here, we discuss the formation of lipid non-lamellar liquid crystalline (LC) surface layers spin-coated from the constituting lipids followed by hydration of the lipid layer. We demonstrate that hybrid lipid polymer films can be formed with different properties compared with the neat lipid LC layers. The nanostructure and morphologies of the lipid films formed reflect those in the bulk. Most notably, mixed lipid layers, which are composed of glycerol monooleate and diglycerol monooleate with poly(N-isopropylacrylamide) nanogels, can form films of reverse cubic phases that are capable of responding to temperature stimulus. Owing to the presence of the nanogel particles, changing the temperature not only regulates the hydration of the cubic phase lipid films, but also the lateral organization of the lipid domains within the lipid self-assembled film. This opens up the possibility for new nanostructured materials based on lipid–polymer responsive layers.
ISSN:2042-8898
2042-8901
2042-8901
DOI:10.1098/rsfs.2016.0150