How to Use CA-125 More Effectively in the Diagnosis of Deep Endometriosis

Deep infiltrative endometriosis (DIE) is a severe form of the disease. The median time interval from the onset of symptoms to diagnosis of endometriosis is around 8 years. In this prospective study patients were divided into two groups: cases (34 DIE patients) and control (20 tubal ligation patients...

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Bibliographic Details
Published in:BioMed research international 2017-01, Vol.2017 (2017), p.1-6
Main Authors: Pereira, Thiago Rodrigues Dantas, Soares, Leila Cristina, Raymundo, Thiers Soares, Oliveira, Marco Aurelio Pinho, Evangelista, Alessandra Viviane
Format: Article
Language:English
Subjects:
Adult
Biomedical research
CA-125 Antigen - blood
Case-Control Studies
Diagnosis
Endometriosis
Endometriosis - blood
Endometriosis - physiopathology
Female
Gynecology
Humans
Laparoscopy
Menstrual Cycle - blood
Menstruation
NMR
Nuclear magnetic resonance
Patients
Performance evaluation
Prospective Studies
Studies
Surgery
Ultrasonic imaging
Womens health
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Summary:Deep infiltrative endometriosis (DIE) is a severe form of the disease. The median time interval from the onset of symptoms to diagnosis of endometriosis is around 8 years. In this prospective study patients were divided into two groups: cases (34 DIE patients) and control (20 tubal ligation patients). The main objective of this study was to evaluate the performance of CA-125 measurement in the menstrual and midcycle phases of the cycle, as well as the difference in its levels between the two phases, for the early diagnosis of DIE. Area Under the Curve (AUC) of CA-125 in menstrual phase and of the difference between menstrual and midcycle phases had the best performance (both with AUC = 0.96), followed by CA-125 in the midcycle (AUC = 0.89). The ratio between menstrual and midcycle phases had the worst performance. CA-125 may be useful for the diagnosis of deep endometriosis, especially when both are collected during menstruation and in midcycle. These may help to decrease the long interval until the definitive diagnosis of DIE. Multicentric studies with larger samples should be performed to better evaluate the cost-effectiveness of measuring CA-125 in two different phases of the menstrual cycle.
ISSN:2314-6133
2314-6141
DOI:10.1155/2017/9857196