Overexpression of PD-L2 is associated with shorter relapse-free survival in patients with malignant salivary gland tumors

PD-1/PD-L1 and CTLA-4 have been investigated and are thought to play an important role in tumor evasion. This study aimed to investigate expression patterns of immune-related molecules, and their clinical impacts in malignant salivary gland tumors. We performed immunohistochemical staining for PD-L1...

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Bibliographic Details
Published in:OncoTargets and therapy 2017-01, Vol.10, p.2983-2992
Main Authors: Chang, Hyeyoon, Kim, Jung Sun, Choi, Yoon Ji, Cho, Jae-Gu, Woo, Jeong-Soo, Kim, Aeree, Kim, Jun Suk, Kang, Eun Joo
Format: Article
Language:English
Subjects:
Biological markers
Cancer therapies
Care and treatment
Chemotherapy
Development and progression
Diagnosis
Histology
Hospitals
Internal medicine
Kidney cancer
Ligands
Lung cancer
Lymphatic system
Lymphocytes
Medical prognosis
Medicine
Melanoma
Oncology
Oral cancer
Original Research
Otolaryngology
Patient outcomes
PD-L1 protein
Prognosis
Radiation therapy
Renal cell carcinoma
Salivary gland tumors
Skin cancer
Tumors
University colleges
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Summary:PD-1/PD-L1 and CTLA-4 have been investigated and are thought to play an important role in tumor evasion. This study aimed to investigate expression patterns of immune-related molecules, and their clinical impacts in malignant salivary gland tumors. We performed immunohistochemical staining for PD-L1, PD-L2, CTLA-4, PD-1, and CD8 tumor-infiltrating lymphocytes in 70 malignant salivary gland tumors. Protein expression was assessed by H-score by multiplying the staining intensity by the percentage of cells with positive staining. The tumors comprised mucoepidermoid carcinomas (38.6%), adenoid cystic carcinomas (21.4%), salivary duct carcinomas (15.7%), and others. In malignant salivary gland tumors, PD-L2 expression was high, while expression of PD-L1 was relatively low in terms of the percentage of positively stained cells and the staining intensity. In univariate analysis, PD-L2 expression (H-score
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S134589