Novel brain expressed RNA identified at the MIR137 schizophrenia-associated locus

Abstract Genome-wide association studies (GWAS) have identified a locus on chromosome 1p21.3 to be highly associated with schizophrenia. A microRNA, MIR137, within this locus has been proposed as the gene causally associated with schizophrenia, due to its known role as a regulator of neuronal develo...

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Bibliographic Details
Published in:Schizophrenia research 2017-06, Vol.184, p.109-115
Main Authors: Gianfrancesco, Olympia, Warburton, Alix, Collier, David A, Bubb, Vivien J, Quinn, John P
Format: Article
Language:English
Subjects:
Brain - metabolism
Cell Line, Tumor
Chromosomes, Human, Pair 1 - genetics
Conserved Sequence - genetics
EU358092
Genetic Loci
Humans
lncRNA
microRNA-137
MicroRNAs - genetics
Psychiatry
Schizophrenia
Schizophrenia - genetics
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Summary:Abstract Genome-wide association studies (GWAS) have identified a locus on chromosome 1p21.3 to be highly associated with schizophrenia. A microRNA, MIR137, within this locus has been proposed as the gene causally associated with schizophrenia, due to its known role as a regulator of neuronal development and function. However, the involvement of other genes within this region, including DPYD (dihydropyrimidine dehydrogenase), is also plausible. In this communication, we describe a previously uncharacterised, brain-expressed RNA, EU358092, within the schizophrenia-associated region at 1p21.3. As we observed for MIR137, EU358092 expression was modulated in response to psychoactive drug treatment in the human SH-SY5Y neuroblastoma cell line. Bioinformatic analysis of publically available CNS expression data indicates that MIR137 and EU358092 are often co-expressed in vivo. A potential regulatory domain for expression of EU358092 is identified by bioinformatic analysis and its regulatory function is confirmed by reporter gene assays. These data suggest a potentially important role for EU358092 in the aetiology of schizophrenia, either individually or in combination with other genes at this locus.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2016.11.034