CYTOMEGALOVIRUS INFECTION IN LIVER TRANSPLANT RECIPIENTS: CURRENT APPROACH TO DIAGNOSIS AND MANAGEMENT

Abstract CMV infection is the most common viral infection in liver transplant recipient that affect post-transplant patient and graft survival. Recent advances in diagnosis and management of CMV has led to marked reduction in incidence, severity and its associated morbidity and mortality. CMV DNA as...

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Bibliographic Details
Published in:Journal of clinical and experimental hepatology 2017-06, Vol.7 (2), p.144-151
Main Authors: Yadav, Sanjay Kumar, Saigal, Sanjiv, Choudhary, Narendra Singh, Saha, Sujit, Kumar, Navin, Soin, Arvinder S
Format: Article
Language:English
Subjects:
CMV disease
cytomegalovirus
Endocrinology & Metabolism
Gastroenterology and Hepatology
infection
liver transplantation
Review
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Summary:Abstract CMV infection is the most common viral infection in liver transplant recipient that affect post-transplant patient and graft survival. Recent advances in diagnosis and management of CMV has led to marked reduction in incidence, severity and its associated morbidity and mortality. CMV DNA assay is the most commonly used laboratory parameter to diagnose and monitor CMV infection. Current evidence suggests both pre-emptive and universal prophylaxis approaches are equally justified in liver transplant recipient. Intravenous ganciclovir and oral valganciclovir are the most commonly used drugs for treatment of CMV disease. Most of the centre use valganciclovir prophylaxis for prevention of CMV disease in liver transplant recipient. The aim of this article is to review current standard of care for diagnosis and management of CMV disease in liver transplant recipients.
ISSN:0973-6883
2213-3453
DOI:10.1016/j.jceh.2017.05.011