Prognostic significance of neutrophil-to-lymphocyte ratio in biliary tract cancers: a systematic review and meta-analysis

Inflammation was considered to perform crucial roles in the development and metastasis of malignancies. A heightened neutrophil-lymphocyte ratio has been described to be associated with detrimental survivals in different malignancies. Debate remains over the impact of heightened neutrophil-lymphocyt...

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Bibliographic Details
Published in:Oncotarget 2017-05, Vol.8 (22), p.36857-36868
Main Authors: Tang, Haowen, Lu, Wenping, Li, Bingmin, Li, Chonghui, Xu, Yinzhe, Dong, Jiahong
Format: Article
Language:English
Subjects:
Biliary Tract Neoplasms - blood
Biliary Tract Neoplasms - mortality
Biliary Tract Neoplasms - pathology
Biliary Tract Neoplasms - therapy
Biomarkers
Humans
Leukocyte Count
Lymphocyte Count
Lymphocytes
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Staging
Neutrophils
Prognosis
Publication Bias
Review
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Summary:Inflammation was considered to perform crucial roles in the development and metastasis of malignancies. A heightened neutrophil-lymphocyte ratio has been described to be associated with detrimental survivals in different malignancies. Debate remains over the impact of heightened neutrophil-lymphocyte ratio on survivals in biliary tract cancer. The review evaluated the prognostic value of neutrophil-lymphocyte ratio in biliary tract cancer. MEDLINE, the Cochrane Library, EMBASE, and the Chinese SinoMed were systematically searched for relevant articles. Associations between neutrophil-lymphocyte ratio and long-term outcomes were expressed as the hazard ratios and 95% confidence intervals. The odds ratio was utilized to assess the association between neutrophil-lymphocyte ratio and clinicopathological parameters. Fourteen studies consisting of 3217 patients were analyzed: 1278 (39.73%) in the high pretreatment neutrophil-lymphocyte ratio group and 1939 (60.27%) in the low pretreatment neutrophil-lymphocyte ratio one. The results proved that heightened pretreatment neutrophil-lymphocyte ratio was significantly associated with detrimental overall survival and relapse free survival for biliary tract cancer patients. In addition, elevated neutrophil-lymphocyte ratio was positively correlated with higher carbohydrate antigen 19-9 levels, advanced TNM staging and greater lymph node involvement. This meta-analysis marked that an increased pretreatment neutrophil-lymphocyte ratio was significantly linked with detrimental long-term outcomes and clinicopathological parameters for patients with biliary tract cancer.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.16143