Molecular Networks Underlying Myofibroblast Fate and Fibrosis

Abstract Fibrotic remodeling is a hallmark of most forms of cardiovascular disease and a strong prognostic indicator of the advancement towards heart failure. Myofibroblasts, which are a heterogeneous cell-type specialized for extracellular matrix (ECM) secretion and tissue contraction, are the prim...

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Bibliographic Details
Published in:Journal of molecular and cellular cardiology 2016-08, Vol.97, p.153-161
Main Authors: Stempien-Otero, April, Kim, Deok-Ho, Davis, Jennifer
Format: Article
Language:English
Subjects:
Actin cytoskeleton
Animals
Biomarkers
Cardiovascular
Cell Differentiation
Differentiation
Fibrosis
Gene Expression Regulation
Gene Regulatory Networks
Humans
Mitogen activated protein kinases
Myofibroblast
Myofibroblasts - cytology
Myofibroblasts - physiology
Phenotype
RNA binding proteins
Signal Transduction
TGFβ
TRP channels
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Summary:Abstract Fibrotic remodeling is a hallmark of most forms of cardiovascular disease and a strong prognostic indicator of the advancement towards heart failure. Myofibroblasts, which are a heterogeneous cell-type specialized for extracellular matrix (ECM) secretion and tissue contraction, are the primary effectors of the heart's fibrotic response. This review is focused on defining myofibroblast physiology, its progenitor cell populations, and the core signaling network that orchestrates myofibroblast differentiation as a way of understanding the basic determinants of fibrotic disease in the heart and other tissues.
ISSN:0022-2828
1095-8584
DOI:10.1016/j.yjmcc.2016.05.002