The relationship between mitochondrial function and walking performance in older adults with a wide range of physical function

Age related declines in walking performance may be partly attributable to skeletal muscle mitochondrial dysfunction as mitochondria produce over 90% of ATP needed for movement and the capacity for oxidative phosphorylation decreases with age. Participants were from two studies: an ancillary to the L...

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Bibliographic Details
Published in:Experimental gerontology 2016-08, Vol.81, p.1-7
Main Authors: Santanasto, Adam J., Coen, Paul M., Glynn, Nancy W., Conley, Kevin E., Jubrias, Sharon A., Amati, Francesca, Strotmeyer, Elsa S., Boudreau, Robert M., Goodpaster, Bret H., Newman, Anne B.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Aging - physiology
Cross-Sectional Studies
Female
Humans
Life Style
Linear Models
Magnetic Resonance Spectroscopy
Male
Mitochondria, Muscle - physiology
Mitochondrial Function
Mobility
Mobility Limitation
Multivariate Analysis
Muscle
Muscle Contraction - physiology
Physical Performance
Quadriceps Muscle - physiology
United States
Walk Test
Walking - physiology
Walking Performance
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Summary:Age related declines in walking performance may be partly attributable to skeletal muscle mitochondrial dysfunction as mitochondria produce over 90% of ATP needed for movement and the capacity for oxidative phosphorylation decreases with age. Participants were from two studies: an ancillary to the Lifestyle Interventions and Independence for Elders (LIFE) Study (n=33), which recruited lower functioning participants (Short Physical Performance Battery [SPPB], 7.8±1.2), and the Study of Energy and Aging-Pilot (SEA, n=29), which enrolled higher functioning (SPPB, 10.8±1.4). Physical activity was measured objectively using the Actigraph accelerometer (LIFE) and SenseWear Pro armband (SEA). Phosphocreatine recovery following muscle contraction of the quadriceps was measured using 31P magnetic resonance spectroscopy and ATPmax (mM ATP/s) was calculated. Walking performance was defined as time (s) to walk 400m at a usual-pace. The cross-sectional association between mitochondrial function and walking performance was assessed using multivariable linear regression. Participants were 77.6±5.3years, 64.2% female and 67.2% white. ATPmax was similar in LIFE vs. SEA (0.52±0.14 vs. 0.55±0.14, p=0.31), despite different function and activity levels (1.6±2.2 vs.77.4±73.3min of moderate activity/day, p
ISSN:0531-5565
1873-6815
DOI:10.1016/j.exger.2016.04.002