An interactive tool for rapid biventricular analysis of congenital heart disease

Summary Cardiac malformations are the most common birth defect. Better interventions in early life have improved mortality for children with congenital heart disease, but heart failure is a significant problem in adulthood. These patients require regular imaging and analysis of biventricular (left a...

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Bibliographic Details
Published in:Clinical physiology and functional imaging 2017-07, Vol.37 (4), p.413-420
Main Authors: Gilbert, K., Lam, H.‐I., Pontré, B., Cowan, B. R., Occleshaw, C. J., Liu, J. Y., Young, A. A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anatomy
Animals
Biomechanical Phenomena
cardiac MRI
Cardiovascular disease
Child
Children
computer‐aided diagnosis
Congenital defects
Congenital diseases
congenital heart disease
Coronary artery disease
Customization
Female
Finite Element Analysis
Finite element method
guide‐point modelling
Heart
Heart Defects, Congenital - diagnostic imaging
Heart Defects, Congenital - physiopathology
Heart diseases
Humans
image analysis
Image Interpretation, Computer-Assisted - methods
Magnetic Resonance Imaging
Male
Models, Cardiovascular
Optimization
Original
Patient-Specific Modeling
Patients
Predictive Value of Tests
Reproducibility of Results
Sheep, Domestic
Three dimensional models
Ventricle
Ventricular Function, Left
Ventricular Function, Right
Young Adult
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Summary:Summary Cardiac malformations are the most common birth defect. Better interventions in early life have improved mortality for children with congenital heart disease, but heart failure is a significant problem in adulthood. These patients require regular imaging and analysis of biventricular (left and right ventricular) function. In this study, we describe a rapid method to analyse left and right ventricular shape and function from cardiac MRI examinations. A 4D (3D+time) finite element model template is interactively customized to the anatomy and motion of the biventricular unit. The method was validated in 17 patients and 10 ex‐vivo hearts. Interactive model updates were achieved through preconditioned conjugate gradient optimization on a multithread system, and by precomputing points predicted from a coarse mesh optimization.
ISSN:1475-0961
1475-097X
DOI:10.1111/cpf.12319