Reproducibility of quantitative indices of lung function and microstructure from 129Xe chemical shift saturation recovery (CSSR) MR spectroscopy

• Published in: Magnetic resonance in medicine 2017-06, Vol.77 (6), p.2107-2113
• Main Authors: Stewart, Neil J., Horn, Felix C., Norquay, Graham, Collier, Guilhem J., Yates, Denise P., Lawson, Rod, Marshall, Helen, Wild, Jim M.
• Format: Article
• Language: English
• Subjects: Alveoli; Carbon monoxide; Chemical equilibrium; chemical shift; Chronic obstructive pulmonary disease; Coefficient of variation; hyperpolarized xenon‐129; Lung diseases; lung function; Magnetic resonance; Magnetic resonance spectroscopy; Microstructure; Obstructive lung disease; Parameter sensitivity; Recovery; Reproducibility; Resonance; Respiratory function; Saturation; Spectroscopic Methodology—Note; Spectroscopy; Spectrum analysis; Thickness; Xenon 129
• ISSN: 0740-3194; 1522-2594
• DOI: 10.1002/mrm.26310

Purpose To evaluate the reproducibility of indices of lung microstructure and function derived from 129Xe chemical shift saturation recovery (CSSR) spectroscopy in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD), and to study the sensitivity of CSSR‐derived parameters to pulse sequence design and lung inflation level. Methods Preliminary data were collected from five volunteers on three occasions, using two implementations of the CSSR sequence. Separately, three volunteers each underwent CSSR at three different lung inflation levels. After analysis of these preliminary data, five COPD patients were scanned on three separate days, and nine age‐matched volunteers were scanned three times on one day, to assess reproducibility. Results CSSR‐derived alveolar septal thickness (ST) and surface‐area‐to‐volume (S/V) ratio values decreased with lung inflation level (P