DNA Polymerase Fidelity: Beyond Right and Wrong

Accurate DNA replication depends on the ability of DNA polymerases to discriminate between correctly and incorrectly paired nucleotides. In this issue of Structure, Batra et al. (2016) show the structural basis for why DNA polymerases do not efficiently add correctly paired nucleotides immediately a...

Full description

Saved in:
Bibliographic Details
Published in:Structure (London) 2016-11, Vol.24 (11), p.1855-1856
Main Author: Washington, M. Todd
Format: Article
Language:English
Subjects:
DNA - genetics
DNA Replication
DNA-Directed DNA Polymerase - chemistry
Nucleotides - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Accurate DNA replication depends on the ability of DNA polymerases to discriminate between correctly and incorrectly paired nucleotides. In this issue of Structure, Batra et al. (2016) show the structural basis for why DNA polymerases do not efficiently add correctly paired nucleotides immediately after incorporating incorrectly paired ones. Accurate DNA replication depends on the ability of DNA polymerases to discriminate between correctly and incorrectly paired nucleotides. In this issue of Structure, Batra et al. (2016) show the structural basis for why DNA polymerases do not efficiently add correctly paired nucleotides immediately after incorporating incorrectly paired ones.
ISSN:0969-2126
1878-4186
DOI:10.1016/j.str.2016.10.003