Individual differences in voluntary alcohol intake in rats: relationship with impulsivity, decision making and Pavlovian conditioned approach

• Published in: Psychopharmacology 2017-07, Vol.234 (14), p.2177-2196
• Main Authors: Spoelder, Marcia, Flores Dourojeanni, Jacques P., de Git, Kathy C. G., Baars, Annemarie M., Lesscher, Heidi M. B., Vanderschuren, Louk J. M. J.
• Format: Article
• Language: English
• Subjects: Aggression; Alcohol Drinking - metabolism; Alcoholic beverages; Alcoholism; Alcohols; Animal cognition; Animals; Approach behavior; Biomedical and Life Sciences; Biomedicine; Choice Behavior - drug effects; Conditioning; Cues; Decision making; Decision Making - drug effects; Dimensional analysis; Ethanol - administration & dosage; Gambling; Impulsive behavior; Impulsive Behavior - physiology; Impulsivity; Male; Neurosciences; Original Investigation; Pharmacology/Toxicology; Physiological aspects; Psychiatry; Rats; Reinforcement; Reward; Rodents
• ISSN: 0033-3158; 1432-2072
• DOI: 10.1007/s00213-017-4617-6

Rationale Alcohol use disorder (AUD) has been associated with suboptimal decision making, exaggerated impulsivity, and aberrant responses to reward-paired cues, but the relationship between AUD and these behaviors is incompletely understood. Objectives This study aims to assess decision making, impulsivity, and Pavlovian-conditioned approach in rats that voluntarily consume low (LD) or high (HD) amounts of alcohol. Methods LD and HD were tested in the rat gambling task (rGT) or the delayed reward task (DRT). Next, the effect of alcohol (0–1.0 g/kg) was tested in these tasks. Pavlovian-conditioned approach (PCA) was assessed both prior to and after intermittent alcohol access (IAA). Principal component analyses were performed to identify relationships between the most important behavioral parameters. Results HD showed more optimal decision making in the rGT. In the DRT, HD transiently showed reduced impulsive choice. In both LD and HD, alcohol treatment increased optimal decision making in the rGT and increased impulsive choice in the DRT. PCA prior to and after IAA was comparable for LD and HD. When PCA was tested after IAA only, HD showed a more sign-tracking behavior. The principal component analyses indicated dimensional relationships between alcohol intake, impulsivity, and sign-tracking behavior in the PCA task after IAA. Conclusions HD showed a more efficient performance in the rGT and DRT. Moreover, alcohol consumption enhanced approach behavior to reward-predictive cues, but sign-tracking did not predict the level of alcohol consumption. Taken together, these findings suggest that high levels of voluntary alcohol intake are associated with enhanced cue- and reward-driven behavior.