Chondroitin sulfates and their binding molecules in the central nervous system

Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a significant affinity with various signalling molecules i...

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Bibliographic Details
Published in:Glycoconjugate journal 2017-06, Vol.34 (3), p.363-376
Main Authors: Djerbal, L, Lortat-Jacob, H, Kwok, JCF
Format: Article
Language:English
Subjects:
Animals
Binding sites
Biochemistry
Biochemistry, Molecular Biology
Biomedical and Life Sciences
Carbohydrate Conformation
Carrier Proteins - chemistry
Carrier Proteins - metabolism
Central nervous system
Central Nervous System - chemistry
Central Nervous System - metabolism
Chondroitin sulfate
Chondroitin Sulfates - chemistry
Chondroitin Sulfates - metabolism
Cognitive ability
Cytokines - chemistry
Cytokines - metabolism
Extracellular Matrix - chemistry
Extracellular Matrix - metabolism
Extracellular Matrix Proteins - chemistry
Extracellular Matrix Proteins - metabolism
Growth factors
Humans
Inhibitors
Intercellular Signaling Peptides and Proteins - chemistry
Intercellular Signaling Peptides and Proteins - metabolism
Life Sciences
Molecules
Nervous system
Neural Cell Adhesion Molecules - chemistry
Neural Cell Adhesion Molecules - metabolism
Neurodegenerative diseases
Neurons - chemistry
Neurons - metabolism
Pathology
Physiology
Protein Binding
Proteins
Proteoglycans - chemistry
Proteoglycans - metabolism
Receptor-Like Protein Tyrosine Phosphatases - chemistry
Receptor-Like Protein Tyrosine Phosphatases - metabolism
Review
Reviews
Structural Biology
Sulfates
Sulfation
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Summary:Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a significant affinity with various signalling molecules in the matrix including growth factors, receptors and guidance molecules. These interactions control numerous biological and pathological processes, during development and in adulthood. In this review, we describe the specific interactions of different families of proteins involved in various physiological and cognitive mechanisms with CSs in CNS matrix. A better understanding of these interactions could promote a development of inhibitors to treat neurodegenerative diseases.
ISSN:0282-0080
1573-4986
DOI:10.1007/s10719-017-9761-z