The Role of Free Radicals in Hemolytic Toxicity Induced by Atmospheric-Pressure Plasma Jet

Atmospheric-pressure plasma (APP) has received attention due to its generation of various kinds of reactive oxygen/nitrogen species (ROS/RNS). The controllability, as well as the complexity, is one of the strong points of APP in various applications. For biological applications of this novel method,...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2017-01, Vol.2017 (2017), p.1-11
Main Authors: Park, Byoungchoo, Park, Hun-Kuk, Kim, Min Su, Kim, Jeongho, Kim, Yong Hee, Huh, Yoon Ho, Baik, Ku Youn, Choi, Eun Ha
Format: Article
Language:English
Subjects:
Animals
Atmospheric Pressure
Blood diseases
Care and treatment
Cells, Cultured
Cytotoxicity
Development and progression
Dogs
Erythrocytes - drug effects
Free Radicals - chemistry
Gases
Health aspects
Hemolysis - drug effects
Hydrogen Peroxide - metabolism
Lipids
Magnetic Resonance Spectroscopy
Mitochondria
Morphology
Nitrates
Nitric oxide
Nitrogen Oxides - metabolism
Oxidative stress
Plasma
Power
Reactive Nitrogen Species - metabolism
Reactive Oxygen Species - metabolism
Spectrum analysis
Spectrum Analysis, Raman
Studies
Toxicity
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Summary:Atmospheric-pressure plasma (APP) has received attention due to its generation of various kinds of reactive oxygen/nitrogen species (ROS/RNS). The controllability, as well as the complexity, is one of the strong points of APP in various applications. For biological applications of this novel method, the cytotoxicity should be estimated at various levels. Herein, we suggest red blood cell (RBC) as a good cell model that is simpler than nucleated cells but much more complex than other lipid model systems. Air and N2 gases were compared to verify the main ROS/RNS in cytotoxicity, and microscopic and spectroscopic analyses were performed to estimate the damages induced on RBCs. The results shown here will provide basic information on APP-induced cytotoxicity at cellular and molecular levels.
ISSN:1942-0900
1942-0994
DOI:10.1155/2017/1289041