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Formation and role of exosomes in cancer
Exosomes offer new insight into cancer biology with both diagnostic and therapeutic implications. Because of their cell-to-cell communication, exosomes influence tumor progression, metastasis, and therapeutic efficacy. They can be isolated from blood and other bodily fluids to reveal disease process...
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| Published in: | Cellular and molecular life sciences : CMLS 2015-02, Vol.72 (4), p.659-671 |
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| Main Authors: | , , , |
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| container_end_page | 671 |
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| container_title | Cellular and molecular life sciences : CMLS |
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| creator | Brinton, Lindsey T Sloane, Hillary S Kester, Mark Kelly, Kimberly A |
| description | Exosomes offer new insight into cancer biology with both diagnostic and therapeutic implications. Because of their cell-to-cell communication, exosomes influence tumor progression, metastasis, and therapeutic efficacy. They can be isolated from blood and other bodily fluids to reveal disease processes occurring within the body, including cancerous growth. In addition to being a reservoir of cancer biomarkers, they can be re-engineered to reinstate tumor immunity. Tumor exosomes interact with various cells of the microenvironment to confer tumor-advantageous changes that are responsible for stromal activation, induction of the angiogenic switch, increased vascular permeability, and immune escape. Exosomes also contribute to metastasis by aiding in the epithelial-to-mesenchymal transition and formation of the pre-metastatic niche. Furthermore, exosomes protect tumor cells from the cytotoxic effects of chemotherapy drugs and transfer chemoresistance properties to nearby cells. Thus, exosomes are essential to many lethal elements of cancer and it is important to understand their biogenesis and role in cancer. |
| doi_str_mv | 10.1007/s00018-014-1764-3 |
| format | article |
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Because of their cell-to-cell communication, exosomes influence tumor progression, metastasis, and therapeutic efficacy. They can be isolated from blood and other bodily fluids to reveal disease processes occurring within the body, including cancerous growth. In addition to being a reservoir of cancer biomarkers, they can be re-engineered to reinstate tumor immunity. Tumor exosomes interact with various cells of the microenvironment to confer tumor-advantageous changes that are responsible for stromal activation, induction of the angiogenic switch, increased vascular permeability, and immune escape. Exosomes also contribute to metastasis by aiding in the epithelial-to-mesenchymal transition and formation of the pre-metastatic niche. Furthermore, exosomes protect tumor cells from the cytotoxic effects of chemotherapy drugs and transfer chemoresistance properties to nearby cells. Thus, exosomes are essential to many lethal elements of cancer and it is important to understand their biogenesis and role in cancer.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-014-1764-3</identifier><identifier>PMID: 25336151</identifier><language>eng</language><publisher>Basel: Springer-Verlag</publisher><subject>Biochemistry ; biogenesis ; biomarkers ; Biomarkers, Tumor - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Biosynthesis ; blood ; Cancer ; Cancer Vaccines - immunology ; Cell Biology ; cell communication ; Cellular biology ; Chemotherapy ; cytotoxicity ; drug therapy ; drugs ; Endosomal Sorting Complexes Required for Transport - metabolism ; Endothelium, Vascular - metabolism ; exosomes ; Exosomes - metabolism ; Fibroblasts - metabolism ; Humans ; immunity ; Leukocytes, Mononuclear - immunology ; Leukocytes, Mononuclear - metabolism ; Life Sciences ; metastasis ; neoplasm cells ; Neoplasm Metastasis ; Neoplasms - diagnosis ; Neoplasms - metabolism ; Neoplasms - therapy ; permeability ; Review ; Tumor Microenvironment ; Tumors ; Vaccines</subject><ispartof>Cellular and molecular life sciences : CMLS, 2015-02, Vol.72 (4), p.659-671</ispartof><rights>Springer Basel 2014</rights><rights>Springer Basel 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-e0e3788b249bc3fe8a7f77d5cbcedfbc1171cfd6b4a6bbe09debbac9e1a46d3f3</citedby><cites>FETCH-LOGICAL-c564t-e0e3788b249bc3fe8a7f77d5cbcedfbc1171cfd6b4a6bbe09debbac9e1a46d3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489338/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489338/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25336151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brinton, Lindsey T</creatorcontrib><creatorcontrib>Sloane, Hillary S</creatorcontrib><creatorcontrib>Kester, Mark</creatorcontrib><creatorcontrib>Kelly, Kimberly A</creatorcontrib><title>Formation and role of exosomes in cancer</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Exosomes offer new insight into cancer biology with both diagnostic and therapeutic implications. Because of their cell-to-cell communication, exosomes influence tumor progression, metastasis, and therapeutic efficacy. They can be isolated from blood and other bodily fluids to reveal disease processes occurring within the body, including cancerous growth. In addition to being a reservoir of cancer biomarkers, they can be re-engineered to reinstate tumor immunity. Tumor exosomes interact with various cells of the microenvironment to confer tumor-advantageous changes that are responsible for stromal activation, induction of the angiogenic switch, increased vascular permeability, and immune escape. Exosomes also contribute to metastasis by aiding in the epithelial-to-mesenchymal transition and formation of the pre-metastatic niche. Furthermore, exosomes protect tumor cells from the cytotoxic effects of chemotherapy drugs and transfer chemoresistance properties to nearby cells. Thus, exosomes are essential to many lethal elements of cancer and it is important to understand their biogenesis and role in cancer.</description><subject>Biochemistry</subject><subject>biogenesis</subject><subject>biomarkers</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biosynthesis</subject><subject>blood</subject><subject>Cancer</subject><subject>Cancer Vaccines - immunology</subject><subject>Cell Biology</subject><subject>cell communication</subject><subject>Cellular biology</subject><subject>Chemotherapy</subject><subject>cytotoxicity</subject><subject>drug therapy</subject><subject>drugs</subject><subject>Endosomal Sorting Complexes Required for Transport - metabolism</subject><subject>Endothelium, Vascular - metabolism</subject><subject>exosomes</subject><subject>Exosomes - metabolism</subject><subject>Fibroblasts - metabolism</subject><subject>Humans</subject><subject>immunity</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Life Sciences</subject><subject>metastasis</subject><subject>neoplasm cells</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - therapy</subject><subject>permeability</subject><subject>Review</subject><subject>Tumor Microenvironment</subject><subject>Tumors</subject><subject>Vaccines</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kUuLFTEQhYMozkN_gBttcDOb1lTevRGGYUaFARc64C4k6cq1h-5kTO4V_ffm0tdhdOEqBfWdk6o6hLwA-gYo1W8rpRRMT0H0oJXo-SNyDILRfqAaHh9qZdjXI3JS622DpWHqKTliknMFEo7J2VUui9tOOXUujV3JM3Y5dvgz17xg7abUBZcClmfkSXRzxeeH95TcXF1-ufjQX396__Hi_LoPUoltjxS5NsYzMfjAIxqno9ajDD7gGH0A0BDiqLxwynukw4jeuzAgOKFGHvkpebf63u38gmPAtC1utndlWlz5ZbOb7N-dNH2zm_zDSmEGzk0zODsYlPx9h3Vrl6kGnGeXMO-qBSWZYIKaPfr6H_Q270pq6zVKGCONMdAoWKlQcq0F4_0wQO0-B7vmYFsOdp-D5U3z8uEW94o_h28AW4HaWmmD5cHX_3F9tYqiy9ZtylTtzWdGQTWSaiYl_w3vYpzr</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Brinton, Lindsey T</creator><creator>Sloane, Hillary S</creator><creator>Kester, Mark</creator><creator>Kelly, Kimberly A</creator><general>Springer-Verlag</general><general>Springer 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Exosomes also contribute to metastasis by aiding in the epithelial-to-mesenchymal transition and formation of the pre-metastatic niche. Furthermore, exosomes protect tumor cells from the cytotoxic effects of chemotherapy drugs and transfer chemoresistance properties to nearby cells. Thus, exosomes are essential to many lethal elements of cancer and it is important to understand their biogenesis and role in cancer.</abstract><cop>Basel</cop><pub>Springer-Verlag</pub><pmid>25336151</pmid><doi>10.1007/s00018-014-1764-3</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biochemistry biogenesis biomarkers Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Biosynthesis blood Cancer Cancer Vaccines - immunology Cell Biology cell communication Cellular biology Chemotherapy cytotoxicity drug therapy drugs Endosomal Sorting Complexes Required for Transport - metabolism Endothelium, Vascular - metabolism exosomes Exosomes - metabolism Fibroblasts - metabolism Humans immunity Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Life Sciences metastasis neoplasm cells Neoplasm Metastasis Neoplasms - diagnosis Neoplasms - metabolism Neoplasms - therapy permeability Review Tumor Microenvironment Tumors Vaccines |
| title | Formation and role of exosomes in cancer |
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