Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association

Purpose. This study was aimed at evaluating sirtuin 4 (Sirt4) levels in obese individuals, in relation to their adherence to the Mediterranean diet (MD), a healthy dietary pattern characterized by high antioxidant capacity, and markers of visceral fat storage. Subjects/Methods. Forty-three obese pat...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2017-01, Vol.2017 (2017), p.1-14
Main Authors: Savastano, Silvia, Falco, Andrea, Macchia, Paolo Emidio, Muscogiuri, Giovanna, Di Somma, Carolina, Tarantino, Giovanni, Barrea, Luigi, Colao, A.
Format: Article
Language:English
Subjects:
Adipocytes
Antioxidants
Blood pressure
Body mass index
Cross-Sectional Studies
Diet
Diet therapy
Diet, Mediterranean
Endocrinology
Fatty acids
Female
Food
Gastrointestinal surgery
Gene expression
Genetic aspects
Health aspects
Humans
Laboratories
Lipids
Lipoproteins
Male
Metabolism
Mitochondrial Proteins - genetics
Mitochondrial Proteins - metabolism
Obesity
Obesity - genetics
Oxidation
Risk Factors
Sirtuins - genetics
Sirtuins - metabolism
Studies
Thyroid gland
Triglycerides
Vegetarianism
Weight control
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Summary:Purpose. This study was aimed at evaluating sirtuin 4 (Sirt4) levels in obese individuals, in relation to their adherence to the Mediterranean diet (MD), a healthy dietary pattern characterized by high antioxidant capacity, and markers of visceral fat storage. Subjects/Methods. Forty-three obese patients (44% males; BMI: 36.7–58.8 kg/m2) were consecutively included. PREvención con DIeta MEDiterránea (PREDIMED) and the 7-day food records were used to assess the adherence to MD and dietary pattern, respectively. Visceral adiposity index (VAI) was calculated. Sirt4 levels were detected by ELISA method. Results. The majority of the obese participants (62.8%) had an average adherence to MD. Compared with average adherers, low adherers had higher BMI, energy intake, and percentage of energy from lipids, mainly saturated fat and polyunsaturated fatty acids (PUFA), and lower Sirt4 levels. After adjusting for BMI, Sirt4 levels remained negatively correlated with VAI. After adjusting for total energy intake, Sirt4 levels remained negatively associated with PREDIMED and consumption of n-3 PUFA, vitamins C and E. The threshold value of PREDIMED predicting the lowest decrease in Sirt4 levels was found at a score of 6. Conclusions. Less reduced Sirt4 levels in obese patients adhering to MD suggest a further aspect of the antioxidant advantage of MD.
ISSN:1942-0900
1942-0994
DOI:10.1155/2017/6101254